ArticleMaterials today. Bio2025
Antioxidant RuCo nanosheet attenuates capsule fibrosis in adhesive capsulitis of shoulder by p38 MAPK signaling pathway inhibition.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review).International journal of molecular medicine · 2026Review
- Signaling pathway networks in frozen shoulder fibrosis: from inflammatory initiation to fibrotic progression.Frontiers in medicine · 2026Review
- From inflammatory activation to fibrotic remodeling: the central role of macrophage heterogeneity in frozen shoulder.Frontiers in immunology · 2026Review
- Clinical efficacy of manipulation under brachial plexus block anesthesia for primary adhesive capsulitis of shoulder: a retrospective cohort study.Frontiers in surgery · 2025Article
- Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesive capsulitis of shoulder (ACS) is a prevalent orthopedic disorder characterized by pain and restricted range of motion (ROM). The pathogenesis of ACS remains unclear and current treatments have limited efficacy in terms of long-term outcomes. Here, we synthesized antioxidant RuCo nanosheets (RuCo-NSs) for the treatment of ACS. The reactive oxygen species (ROS) scavenging ability and the effect of RuCo-NSs on the activation of mouse fibroblasts NIH3T3s were investigated. In addition, RuCo-NSs were administered to the mouse model of ACS through intra-articular injection into joint capsule. Results showed that RuCo-NSs could effectively scavenge ROS in both the acellular and intracellular environments with low toxicity. Moreover, RuCo-NSs significantly suppressed the proliferation, migration and fibrogenesis of NIH3T3 via modulating the p38 mitogen-activated protein kinase (MAPK) signaling pathway. In addition, RuCo-NSs improved shoulder stiffness and inhibited capsular fibrosis in ACS mice. Our results suggest that the use of RuCo-NSs may be a potential therapy for ACS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.