ArticleEJIFCC2025
Reference Intervals of Thyrotropin, Thyroid Hormones, and Thyroid Autoantibodies in Adult and Older Individuals According to Iodine Status.
Article in EJIFCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Age- and Sex-Specific Reference Intervals for TSH, FT4, and FT3 Derived from the Turkish Multi-Center Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- TSH reference intervals among Sub-Saharan African adults: a pilot study in Cameroon.BMC endocrine disorders · 2026Article
- Article
- Reference Intervals and Cut-Off Values for Thyroid Tests in the Croatian Adult Population on the Snibe MAGLUMI X6 Immunoassay Analyzer.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background-Aim: Several factors, including ethnicity, age, iodine status, and assay method, can influence thyroid test results. This study aimed to establish reference intervals (RIs) for thyroid parameters in adults and older individuals, considering their iodine statuses. Methods: A cross-sectional study at a single tertiary center was conducted. Participants underwent interviews, physical examinations, thyroid ultrasounds, thyroid autoantibody testing, and a spot urine iodine concentration analysis. The included participants were grouped into adult (age 18 - 59) and older (age ≥60) groups. The studies for 2.5th-97.5th values of thyroid parameters were committed to establishing RIs. Results: A total of 357 individuals were screened, with 216 (112 adults, 54% women, 104 older, 50% women) were included in the analysis. The RIs for thyroid stimulating hormone (TSH) were as follows: 0.39 - 4.17 mIU/L for the overall group, 0.35 - 3.98 mIU/L in the adult group, and 0.42 - 4.83 mIU/L in the older group. The prevalence of adequate iodine intake (urine iodine level ≥ 200 μg/L) was 62.2% (186/299). Though RIs for TSH, Free T4, and Free T3 were slightly higher in the adequate iodine intake group, no statistically significant differences were noted. Positive anti-thyroglobulin antibodies were more prevalent in older participants (27.3% VS. 21.2%), as were anti-thyroid peroxidase antibodies (24.2% VS. 13.9%). Conclusion: Older individuals exhibited significantly higher TSH levels and lower FT3/Total T3 levels, while FT4/Total T4 remained comparable to adults. All thyroid parameters and thyroid autoantibody levels showed no statistically significant differences between those with adequate iodine intake and those with iodine deficiency.
Indexed as
Identifiers
40584977PMC12205146What OpenQuestion holds
Registered trials
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