Evidence map›Paper›PMID 40584958›Full record

ArticleTherapeutic advances in urology

Impact of smoking status at diagnosis on oncological outcomes of upper-tract urothelial carcinoma.

Hongda Zhao, Kang Liu, Alfonso Crisci, Ed Te Slaa, Tomonori Habuchi, Murat Akand, Chi Fai Ng, Pilar Laguna, Jeremy Yuen-Chun Teoh, Jean de la Rosette

Registry-linked trialAbstract read
In one paragraph

Article in Therapeutic advances in urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02281188 (Registry for Treatment of Upper Urinary Tract Tumours; A Multi-Center, International Registry to Evaluate the Treatment of Upper Tract Urothelial Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02281188 unknown statusnot on this map

Registry for Treatment of Upper Urinary Tract Tumours; A Multi-Center, International Registry to Evaluate the Treatment of Upper Tract Urothelial Cancer: Incidence, Indications, Treatment Types and Outcomes.

Typeobservational_patient_registrySponsorClinical Research Office of the Endourological SocietyRan2014 to 2024Enrolled2,451ConditionsUpper Urinary Tract Tumours
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongda ZhaoS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0003-2414-1484
Kang LiuS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Alfonso CrisciDepartment of Urology, Careggi Hospital, University of Florence, Florence, Italy.
Ed Te SlaaDepartment of Urology, Isala Klinieken, Zwolle, The Netherlands.
Tomonori HabuchiDepartment of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Murat AkandDepartment of Urology, School of Medicine, Selcuk University, Selçuklu, Turkey.
Chi Fai NgS.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Pilar LagunaIstanbul Medipol University, Istanbul, Turkiye.
Jeremy Yuen-Chun TeohDepartment of Surgery, 4/F LCW Clinical Sciences Building, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Jean de la RosetteIstanbul Medipol University, Istanbul, Turkiye.ORCID https://orcid.org/0000-0002-6308-1763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The evidence supporting personalized surveillance strategies for upper-tract urothelial carcinoma (UTUC) remains limited. This study seeks to explore how smoking habits influence the oncological outcomes of UTUC. Methods: Data on disease characteristics from UTUC patients were gathered prospectively. Recurrence-free survival was the primary outcome measured. Patients were stratified based on smoking status for Kaplan-Meier and multivariable Cox regression analyses. Results: A total of 1952 patients were involved, including 684 (35%) patients who never smoked, 572 (29%) that were ex-smokers, and 696 (36%) that were current smokers. For female patients, most of them were nonsmokers ( Conclusion: Smoking at the time of diagnosis was significantly associated with an increased risk of tumor recurrence in the bladder but not significantly in the upper urinary tract. This study confirms that cumulative smoking exposure accelerates the risk of tumor recurrence and underlines the importance of smoking cessation. Trial registration: NCT02281188.

Indexed as

oncological outcomesrecurrencesmokingupper tract urothelial carcinoma

Identifiers

PMID40584958
PMCPMC12206271

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.