ArticleEuropean heart journal. Imaging methods and practice2025
Long-term cardiovascular consequences of cancer therapy-related cardiac dysfunction: insights from ventricular-arterial coupling and myocardial work.
Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: Ventricular-arterial (VA) coupling and myocardial work can assess the interaction between the left ventricle and the arterial system and provide insight into cancer-therapy-related cardiac dysfunction (CTRCD). This study assessed the relationship between VA coupling and myocardial work indices with CTRCD in breast cancer (BC) survivors. Methods and results: In this cross-sectional case-control study, 42 human epidermal growth factor receptor 2-positive BC survivors [22 with a history of CTRCD (TOX), 20 without CTRCD (NOTOX)] and 15 age-matched healthy controls (HC) prospectively underwent echocardiography and cardiopulmonary exercise testing. VA coupling measures were arterial elastance (Ea) and end-systolic elastance (Ees), with increased Ea/Ees indicating ventricular-arterial uncoupling. Myocardial work measures included global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE). Linear regression models assessed associations between VA coupling and myocardial work indices with cardiorespiratory fitness, measured by peak oxygen consumption (VO Conclusion: CTRCD is associated with VA uncoupling in BC survivors, the mechanism of which may be increased arterial load. Studies to evaluate whether reducing arterial load can mitigate VA uncoupling are needed.
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