Evidence map›Paper›PMID 40584830›Full record

ArticleFrontiers in genetics2025

Reduced T-Cell stemness underlies Th17 expansion and graft dysfunction in kidney transplant recipients.

Chang Liu, Hao Jiang, Andu Zhu, Chen Xu, Zhenfan Wang, Guocai Mao, Minjun Jiang, Jianchun Chen, Zheng Ma, Jiaqian Qi and 1 more

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In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Chang Liu *Department of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Hao Jiang *Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Andu Zhu *Department of Clinical Laboratory, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Chen XuDepartment of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Zhenfan WangDepartment of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Guocai MaoDepartment of Thoracic Surgery, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Centre of Soochow University, Suzhou, China.
Minjun JiangDepartment of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Jianchun ChenDepartment of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Zheng MaDepartment of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.
Jiaqian QiDepartment of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhijun CaoDepartment of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: End-stage renal disease (ESRD) is increasing worldwide, and although kidney transplantation improves survival, long-term graft loss-driven mainly by immune-mediated rejection-remains common. We aimed to delineate immune mechanisms that distinguish recipients with stable versus impaired graft function. Methods: Peripheral blood mononuclear cells from kidney-transplant recipients with normal (n = 10) or impaired (n = 10) renal function were profiled by single-cell RNA sequencing. Fourteen immune populations were identified; CD4 Results: Recipients with graft dysfunction exhibited (i) expansion of Th17 cells and contraction of Treg cells, (ii) significant loss of CD4 Discussion: Integrative single-cell and bulk analyses link diminished CD4

Indexed as

immune regulationkidney transplantationS100 proteinsT-cell stemnessTh17 cells

Identifiers

PMID40584830
PMCPMC12202220

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