Evidence map›Paper›PMID 40584789›Full record

ArticleRegenerative medicine reports2025

SNRK facilitates cardiac repair associated with nonischemic fibrosis: regulating transforming growth factor-beta1 levels in atrial cardiomyocytes.

Karthikeyan Thirugnanam, Farhan Rizvi, Arshad Jahangir, Peter Homar, Fathima Shabnam, Sean P Palecek, Suresh N Kumar, Amy Pan, Xiaowen Bai, Hidekazu Sekine and 1 more

Abstract read
In one paragraph

Article in Regenerative medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Transcriptomic Association of COL3A1Pain research & management · 2026
    Article
  3. Integrative single-cell analysis revealsFrontiers in immunology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Karthikeyan ThirugnanamDepartment of Pediatrics, Division of Neonatology, Developmental Vascular Biology Program, Children's Research Institute (CRI), Milwaukee, WI, USA.
Farhan RizviAurora Cardiovascular and Thoracic Services, Advocate Health, Milwaukee, WI, USA.
Arshad JahangirAurora Cardiovascular and Thoracic Services, Advocate Health, Milwaukee, WI, USA.
Peter HomarAurora Cardiovascular and Thoracic Services, Advocate Health, Milwaukee, WI, USA.
Fathima ShabnamDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Sean P PalecekDepartment of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Suresh N KumarDepartment of Pathology, Division of Pediatric Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
Amy PanDepartment of Pediatrics, Division of Bioinformatics and Quantitative Child Health, Milwaukee, WI, USA.
Xiaowen BaiDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Hidekazu SekineInstitute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan.
Ramani RamchandranDepartment of Pediatrics, Division of Neonatology, Developmental Vascular Biology Program, Children's Research Institute (CRI), Milwaukee, WI, USA.ORCID 0000-0002-3555-6119

Funding

Mitochondria and anesthetic-induced developmental neurotoxicityR35GM148177 · NIGMS · OHIO STATE UNIVERSITY · PI Xiaowen Bai · 2023 to 2026
$1.7M
Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebratesR01HL102745 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2011 to 2014
$1.5M
NHLBI NIH HHS R01 HL102745NIGMS NIH HHS R35 GM148177
6 · The paper itself

Abstract

Heart failure is a pressing clinical condition that is expected to increase as our population ages and thus requires better treatment options. Identifying the precise mechanisms that underlie fibrosis and inflammation, two key features associated with cardiac repair and regeneration during ischemic and nonischemic heart failure, is likely to provide effective strategies for the clinical intervention of heart failure. This study investigated a metabolic serine threonine kinase gene, sucrose nonfermenting-related kinase (

Indexed as

cardiac repaircardiomyocyteheart failureHL-1paracrineregenerationregenerative medicinetransforming growth factor-β1

Identifiers

PMID40584789
PMCPMC12204380

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.