ArticleFrontiers in medicine2025
Analysis of the impact of clinical practices on salivary biomarkers of inflammation and stress in oral surgery postgraduate students: a pilot study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: To assess through salivary biomarkers if clinical practices generate stress and a systemic inflammatory response in dental surgery post-graduate students. Materials and methods: A cross-sectional analytical observational study was conducted with students from the Master's in Clinical Dentistry program. Salivary samples were collected before and after surgical procedures to quantify stress (cortisol) and inflammation biomarkers (IL-6, IL-1β, and CRP). Additionally, students completed the Perceived Stress Scale (PSS) questionnaire prior to the surgical procedure. Descriptive and analytic statistics were conducted with a 95% significance level. Results: A total analyzed sample included 21 subjects, with a mean age of 25.5 years. The influence of academic year, gender, or smoking status was none found to have a significant impact. The results show a significant decrease in cortisol levels between the pre- and post-measurements (mean difference = -108.2 ± 166.7). However, an increase in IL-6 levels was obtained ( Conclusion: The findings show a significant decrease in salivary cortisol (stress) levels and a significant increase in salivary IL-6 levels following a dental implantology procedure in postgraduate oral surgery students.
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