Evidence map›Paper›PMID 40584633›Full record

ArticleNeurology. Clinical practice2025

Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease.

Nicholas U Schwartz, Connor D Dietz, Igor Prufer Araújo, Javier E Villanueva-Meyer, Winston Chiong, Courtney Lane-Donovan, Lawren Vandevrede, Peter A Ljubenkov, Yingbing Wang, David N Soleimani-Meigooni and 2 more

Abstract read
In one paragraph

Article in Neurology. Clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Regulatory, clinical, and post-marketing challenges of lecanemab for Alzheimer's disease: insights from real-world data.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nicholas U SchwartzMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0003-1040-7819
Connor D DietzMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.
Igor Prufer AraújoMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco.
Winston ChiongMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0001-9188-1920
Courtney Lane-DonovanMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0001-9504-8346
Lawren VandevredeMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0002-8304-6711
Peter A LjubenkovMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0002-3348-9215
Yingbing WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco.
David N Soleimani-MeigooniMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.
Renaud La JoieMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0003-2581-8100
Julio C RojasMemory and Aging Center, Weill Institute for Neurosciences, University of California, San Francisco; and.ORCID https://orcid.org/0000-0002-1308-646X

Funding

Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Development of Emergent PET Tracers in Frontotemporal Lobar DegenerationK23AG076960 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David Nima Soleimani-Meigooni · 2022 to 2026
$951k
Illuminating Lysosomal Dysfunction in Aging and Alzheimer's Disease (AD)K08AG083050 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Courtney E Lane-Donovan · 2023 to 2026
$712k
NIA NIH HHS K08 AG083050NIA NIH HHS K23 AG076960NIA NIH HHS T32 AG023481
6 · The paper itself

Abstract

Background and Objectives: Antiamyloid immunotherapies are associated with increased risk of intracerebral hemorrhage, particularly in the setting of Methods: We describe a case of a patient with Alzheimer disease (AD) with an incidental cavernous malformation treated with lecanemab. Results: A 73-year-old Discussion: Lecanemab therapy was associated with asymptomatic expansion of an incidental cavernous malformation in a patient with AD and without evidence of ARIA.

Identifiers

PMID40584633
PMCPMC12204771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.