Mechanistic Insights and Anti-cancer Activity of 2H-benzo[b][1,4]oxazin-3(4H)-one Linked 1,2,3-Triazoles in Human Cancer Cells.

Qingying Liu, Xixi Hou, Mingyue Tian, Baoyu He, Jingjing Guo, Yajie Guo, Jianxue Yang

Abstract read

In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qingying LiuThe First Affiliated Hospital , and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.

Xixi HouThe First Affiliated Hospital , and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.

Mingyue TianDepartment of Pain Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Baoyu HeCentre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.

Jingjing GuoCentre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.

Yajie GuoDepartment of Emergency, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.

Jianxue YangThe First Affiliated Hospital , and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives linked to 1,2,3-triazoles were designed, synthesized, and evaluated for their anticancer activity in several human cancer cell lines, including A549 (lung), Huh7 (liver), MCF-7 (breast), HCT-116 (colon), and SKOV3 (ovary). Cell viability assays revealed that these compounds exhibited the most potent activity against A549 cells. Among them, compounds 14b and 14c demonstrated the strongest inhibitory effects, with IC

Indexed as

1, 2, 3-triazole2H-benzo[b][1,4]oxazin-3(4H)-oneanticancerapoptosisDNA damageROS

Identifiers

PMID40584621

DOI10.3389/fphar.2025.1565657

PMCPMC12202533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.