ReviewFrontiers in pharmacology2025
Lactate-induced lactylation: from basic research to clinical perspectives.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Exercise-induced protein lactylation: From molecular mechanisms to precision health applications.iScience · 2026Review
- Lactate dynamics in Parkinson's disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows.Molecular medicine (Cambridge, Mass.) · 2026Review
- Lactylation: a novel post-translational modification for cGAS-STING pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- A Novel Approach to Neuropathic Pain Treatment: Lactylation Targeting Microglia.Molecular neurobiology · 2026Review
- Lactylation in cardiac repair: Nexus and therapeutic opportunity.Journal of molecular and cellular cardiology plus · 2026Review
- Lactylation-Related Genes in Ulcerative Colitis: A Multiomics Mendelian Randomization Study for Therapeutic Target Discovery.Human mutation · 2026Article
- Role of lactylation modification in regulating lytic cell death.Frontiers in oncology · 2026Review
- Protein lactylation in Alzheimer's disease: bridging metabolism, pathology, and therapeutic opportunity.Frontiers in aging neuroscience · 2026Review
- Targeting Lactylation Offers Therapy to Reverse Cell Death Resistance.Drug design, development and therapy · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactate was initially considered a metabolic waste product of glycolysis under hypoxic conditions until the emergence of the lactate shuttle hypothesis. The lactate shuttle hypothesis describes the role of lactate in the delivery of oxidative and gluconeogenic substrates as well as in cell signaling. Lactate is a key molecule that links cellular metabolism to the regulation of cellular activity. Lactate-induced lactylation was first identified and reported in Nature in 2019 by Zhang et al. Subsequently, many studies on lactylation have been reported. Widely distributed lactylation is involved in a myriad of pathological processes and participates in the development and progression of numerous diseases, offering promising potential for future disease treatments. We comprehensively reviewed and organized the existing literature, detailed the metabolic processes of lactate and lactylation, and summarized the existing research methods on lactylation, aiming to provide direction and convenience for future research in this field. Additionally, we summarized the role of lactylation in various pathophysiological processes and elucidated the relationship between lactate modification and various diseases, as well as the targets and drugs that regulate lactylation, which may enable future clinical interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.