Evidence map›Paper›PMID 40584566›Full record

ArticleSurgical case reports2025

Long-Term Survival Following Multimodal Therapy with Sunitinib and Surgery for Recurrent Duodenal Gastrointestinal Stromal Tumor.

Manatsu Mizuno, Tsuyoshi Takahashi, Yoshito Tomimaru, Yukinori Kurokawa, Takuro Saito, Takaomi Hagi, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino and 5 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Manatsu MizunoDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Tsuyoshi TakahashiDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Yoshito TomimaruDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Yukinori KurokawaDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Takuro SaitoDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Takaomi HagiDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Kota MomoseDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Kotaro YamashitaDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Koji TanakaDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Tomoki MakinoDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Kiyokazu NakajimaDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Tomomi FujiiDepartment of Pathology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Eiichi MoriDepartment of Pathology, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, The University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGastrointestinal stromal tumors (GISTs) are mesenchymal tumors often driven by CASE PRESENTATION: A 77-year-old male presented with multiple liver and peritoneal metastases from a duodenal GIST. Initial treatment with imatinib was discontinued due to adverse effects, and sunitinib was initiated, maintaining disease stability for 7 years. Disease progression as a solitary lesion in liver segment seven was identified via imaging and diagnosed as sunitinib-resistant. A laparoscopic partial hepatectomy was performed, achieving complete resection without complications. Postoperative resumption of sunitinib has controlled all other lesions for 9 years with no recurrence.

conclusionsThis case highlights the potential of combining sunitinib with surgery to manage drug-resistant GIST. Localized surgical resection of resistant lesions, integrated with systemic therapy, may offer prolonged survival in selected patients. Further studies are needed to define the optimal role of surgery in this context.

Indexed as

drug resistancegastrointestinal stromal tumor (GIST)KIT mutationmultimodal treatmentprogression-free survivalsunitinibsurgical intervention

Identifiers

PMID40584566
PMCPMC12206549

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