Evidence map›Paper›PMID 40584560›Full record

ArticleISME communications2025

Unexpected diversity and ecological significance of uncultivable large virus-like particles in aquatic environments.

Hermine Billard, Maxime Fuster, François Enault, Jean-François Carrias, Léa Fargette, Margot Carrouée, Perrine Desmares, Tom O Delmont, Pauline Nogaret, Estelle Bigeard and 5 more

Abstract read
In one paragraph

Article in ISME communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hermine BillardLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.
Maxime FusterLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.
François EnaultLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.ORCID https://orcid.org/0000-0002-4968-3995
Jean-François CarriasLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.ORCID https://orcid.org/0000-0002-6201-1544
Léa FargetteLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.
Margot CarrouéeLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.
Perrine DesmaresLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.
Tom O DelmontGénomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ. Evry, Université Paris-Saclay, Evry, France.
Pauline NogaretSorbonne Université CNRS, Station Biologique de Roscoff, UMR, 7144, Roscoff, France.
Estelle BigeardSorbonne Université CNRS, Station Biologique de Roscoff, UMR, 7144, Roscoff, France.
Gwenn TanguySorbonne Université CNRS, Station Biologique de Roscoff, FR2424, Roscoff, France.
Anne-Claire BaudouxSorbonne Université CNRS, Station Biologique de Roscoff, UMR, 7144, Roscoff, France.
Urania ChristakiUMR CNRS 8187 LOG, Université Littoral Côte d'Opale, Université de Lille, Wimereux, France.
Télesphore Sime-NgandoLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.
Jonathan ColombetLaboratoire Microorganismes : Génome et Environnement (LMGE), UMR CNRS 6023, Université Clermont-Auvergne, F-63000 Clermont-Ferrand, France.ORCID https://orcid.org/0000-0003-3763-6566

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery of jumbo phages and giant viruses of microeukaryotes has transformed our perception of the virosphere. Metagenomic and metatranscriptomic data further highlight their diversity and ecological impact. Nevertheless, sequence-based approaches fail to take into account the morphological diversity of non-cultivated viruses, resulting in our fragmented understanding of their nature and role in the environment. Here, we combined flow cytometry and electron microscopy to uncover both previously unsuspected morphological diversity and significant abundances of large virus-like particles in aquatic environments. We discovered new viral morphotypes, all likely to be associated with microeukaryotes. We also obtained insights into the multi-year dynamics of the abundances of both giant microeukaryotic virus-like particles and jumbo phage-like particles. This work deepens our understanding of large virus and reveals their key role as regulators of microbial communities.

Indexed as

giant virusjumbo phagesviral diversityviral ecology

Identifiers

PMID40584560
PMCPMC12204322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.