Evidence map›Paper›PMID 40584457›Full record

ArticlePhysics and imaging in radiation oncology2025

Predicting the hypoxic volume of head and neck tumors from fluorodeoxyglucose positron emission tomography images using artificial intelligence.

Wei Zhao, Milan Grkovski, Heiko Schoder, Aditya P Apte, John Humm, Nancy Y Lee, Joseph O Deasy, Harini Veeraraghavan

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei ZhaoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center New York, 321 East 61st Street, NY 10065, USA.
Milan GrkovskiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center New York, 321 East 61st Street, NY 10065, USA.
Heiko SchoderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, USA.
Aditya P ApteDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center New York, 321 East 61st Street, NY 10065, USA.
John HummDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center New York, 321 East 61st Street, NY 10065, USA.
Nancy Y LeeDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, USA.
Joseph O DeasyDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center New York, 321 East 61st Street, NY 10065, USA.
Harini VeeraraghavanDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center New York, 321 East 61st Street, NY 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Safer lung cancer radiotherapy delivery using novel artificial intelligence methodsR01CA258821 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Harini Veeraraghavan · 2022 to 2026
$2.5M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA258821
6 · The paper itself

Abstract

Background and purpose: Tumor hypoxia is linked to lower local control rates and increased distant disease progression during head and neck (HN) radiotherapy. Materials and methods: One hundred and thirty-four (training = 84, validation = 13, testing = 21, additional testing = 16) HN carcinoma patients, treated with chemoradiotherapy between 2011 and 2018 and scanned at treatment baseline with Results: The AI model hypoxic volume predictions were well-correlated with Conclusion: Voxel-wise prediction of hypoxia for HN cancers from a 2D deep learning model using FDG-PET images as inputs was shown to be feasible. Testing on larger institutional and multi-institutional cohorts is required to establish generalizability.

Indexed as

Deep learningFDGFMISOGenerative adversarial networkHead and neck cancerHypoxia

Identifiers

PMID40584457
PMCPMC12206312

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.