ArticleIranian journal of basic medical sciences2025
Mitotherapy attenuates sepsis-induced brain injury in rats subjected to cecal ligation and puncture: Role of SIRT-1/PGC-1α network.
Article in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Lactylation: a novel epigenetic bridge connecting metabolic reprogramming and immune dysregulation in sepsis-associated ARDS.Frontiers in immunology · 2026Review
- The Role of Mitochondrial Complexes in Liver Diseases.Journal of clinical and translational hepatology · 2025Review
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Authors and funding
6 authors.
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Abstract
Objectives: Sepsis-induced brain injury poses a critical challenge with limited therapeutic options. Mitochondrial dysfunction is a central contributor to this pathogenesis. The current work aimed to examine the effects of mitochondrial transplantation, termed "mitotherapy", on sepsis-induced brain injury using a cecal ligation and puncture (CLP) rat model. Materials and Methods: Male Wistar rats (n=40, 12 weeks old, weighing 250-300 g) were allocated into groups with or without CLP-induced sepsis, receiving mitotherapy via single or two repetitive injections post-CLP. In recipient groups, mitochondria harvested from donor rats were injected intravenously (400 μl of mitochondrial suspension containing 7.5×10 Results: Mitotherapy reduced MSS and alleviated histopathological changes associated with sepsis-induced brain injury. Furthermore, it restored mitochondrial functional indices, up-regulated genes involved in mitochondrial biogenesis and fusion, and reduced inflammatory cytokine levels ( Conclusion: Mitotherapy mitigated sepsis-induced brain injury by improving mitochondrial function, biogenesis, and dynamics within the SIRT-1/PGC-1α network and concurrently suppressing inflammation. Repetitive injections exhibited enhanced potency, suggesting a novel avenue for managing sepsis-associated brain dysfunction.
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