Evidence map›Paper›PMID 40584426›Full record

ArticleIBRO neuroscience reports2025

Neural stem cell changes and spatial distribution of AQP4 expression in a fetal goat model of obstructive hydrocephalus.

Xinting Ji, Qin Zhang, Yuantao Yang, Yan Li, Lihong Li, Shibin Lin, Qi Dong, Zhenling Wan, Julan Wu, Jiadong Bao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xinting JiDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Qin ZhangDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Yuantao YangDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Yan LiDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Lihong LiDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Shibin LinDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Qi DongDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Zhenling WanDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Julan WuDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Jiadong BaoDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Xiaoman SuDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.
Pengzhi ChenKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Chenyuan LiuKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Weian SongKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Zechen WangKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Kang FengKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Xiaoying LiKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Shaojiang ZhengKey Laboratory of Emergency and Trauma of Ministry of Education, Hainan Engineering Research Center for Biological Sample Resources of Major Diseases, The First Clinical College & The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.
Shuo GuDepartment of Pediatric Neurosurgery and Collaborating Departments (Anesthesiology, Obstetrics, Pathology, Ultrasound, General Surgery),Hainan Women's and Children's Medical Center, The Pediatric College, Hainan Medical University, Haikou, Hainan 570000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fetal ventriculomegaly (VM) is a common congenital abnormality with poor outcomes in severe cases, the mechanisms of which include cerebrospinal fluid（CSF）circulation disorders and abnormal neural development. While Aquaporin 4 (AQP4) plays an important role in CSF circulation, its expression in fetal VM has not been fully studied. Methods: Fetal goats at 90-100 days of gestation were divided into experimental (hydrocephalus induced by BioGlue ® injection) and control (untreated cotwin) groups. Ventricular changes were monitored using ultrasound and magnetic resonance imaging Results: The ventricles of hydrocephalic goats were significantly enlarged (> mean + 2 SDs) compared with controls. The number of proliferating neural stem cells in the subventricular zone decreased significantly (P < 0.01). Microglial and astrocyte numbers increased significantly in the hydrocephalus group (P < 0.01). AQP4 expression was higher in the corpus callosum, periventricular, and subventricular zones (P < 0.01), with the largest increase in the subventricular zone. AQP4 expression correlated with the increase in IBA1-positive cells (r = 0.979, P = 0.004; r = 0.991, P < 0.001). Conclusion: This study revealed pathological changes following fetal VM as well as the spatial expression of AQP4. These findings provide insights into the pathological changes associated with fetal VM and identify potential therapeutic targets.

Indexed as

Aquaporin 4 (AQP4)BioGlue-induced hydrocephalusFetal goatHydrocephalusNeural stem cells

Identifiers

PMID40584426
PMCPMC12203870

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