Evidence map›Paper›PMID 40584420›Full record

ArticleIBRO neuroscience reports2025

The reduction in locomotor activity induced by restraint stress in young male mice involves the downregulation of hippocampal serotonergic and dopaminergic markers.

Megumi Furukawa, Nobuo Izumo, Masahiro Toho, Ryoken Aoki, Hiroki Nishijima, Yusuke Nakamura, Yumi Sakai, Yukiko Ishibashi, Haruna Kurono, Takayuki Manabe and 1 more

Abstract read
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In one paragraph

Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Megumi FurukawaDepartment of Functional Brain Activities, United Graduate School of Child Development, Hamamatsu University School of Medicine, Osaka University, Kanazawa University, Chiba University, and University of Fukui, Osaka, Japan.
Nobuo IzumoLaboratory of Pharmacotherapy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
Masahiro TohoLaboratory of Pharmacotherapy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
Ryoken AokiDepartment of Functional Brain Activities, United Graduate School of Child Development, Hamamatsu University School of Medicine, Osaka University, Kanazawa University, Chiba University, and University of Fukui, Osaka, Japan.
Hiroki NishijimaLaboratory of Pharmacotherapy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
Yusuke NakamuraLaboratory of Pharmacotherapy, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
Yumi SakaiDepartment of Functional Brain Activities, United Graduate School of Child Development, Hamamatsu University School of Medicine, Osaka University, Kanazawa University, Chiba University, and University of Fukui, Osaka, Japan.
Yukiko IshibashiLaboratory of Drug Analysis, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa 245-0066, Japan.
Haruna KuronoLaboratory for Neuroanatomy and Neuropharmacology, Research Field of Basic Medicine, Department of Nursing, Faculty of Nursing, Chukyogakuin University, 2216 Toki-cho, Mizunami, Gifu 509-6192, Japan.
Takayuki ManabeDepartment of Functional Brain Activities, United Graduate School of Child Development, Hamamatsu University School of Medicine, Osaka University, Kanazawa University, Chiba University, and University of Fukui, Osaka, Japan.
Hideo MatsuzakiDepartment of Functional Brain Activities, United Graduate School of Child Development, Hamamatsu University School of Medicine, Osaka University, Kanazawa University, Chiba University, and University of Fukui, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The novel coronavirus (COVID-19) pandemic led to widespread restrictions on human activities, including limits on physical activity and public gatherings. In particular, the physical and mental effects of restricting childhood activities such as exercise and play urgently need to be elucidated. In this study, we analyzed the effects of restraint stress on young (4-week-old) and adult (10-week-old) mice using behavioral experiments and gene expression analysis. Restraint stress did not cause a decrease in the expression of BDNF, a depression marker, in the hippocampus, suggesting that it may be a relatively mild form of stress. In young mice, restraint stress caused significant reductions in locomotor activity and sucrose preference. In contrast, in adult mice, no significant difference was observed in locomotor activity or sucrose preference. Increased expression of the

Indexed as

CatecholamineHippocampusLocomotor activityRestraint stressSerotoninSucrose preference test

Identifiers

PMID40584420
PMCPMC12203867

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.