ArticleEndocrine oncology (Bristol, England)2025
Adrenal crisis due to pembrolizumab-induced hypophysitis in a patient with triple-negative breast cancer.
Article in Endocrine oncology (Bristol, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Clinical characteristics, management, and prognosis of pembrolizumab-induced hypophysitis: retrospective analysis based on case reports.Frontiers in immunology · 2026Article
- Article
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3 authors.
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Abstract
We report a case of a 43-year-old woman with stage IIB triple-negative breast cancer (TNBC) on neoadjuvant pembrolizumab presenting in adrenal crisis. Biochemical evaluation revealed isolated adrenocorticotropic hormone (ACTH) deficiency, and MRI demonstrated a partial empty sella; findings consistent with pembrolizumab-induced hypophysitis. Glucocorticoid replacement therapy led to symptom resolution. Pembrolizumab-induced hypophysitis is rare (incidence ∼0.98%), often associated with isolated ACTH deficiency, making diagnosis challenging due to nonspecific symptoms and frequently unremarkable pituitary imaging. As ICI use expands, clinician awareness of immune-related adverse effects (irAEs) is essential to prevent life-threatening complications and improve outcomes.
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