Evidence map›Paper›PMID 40584402›Full record

ArticleInternational journal of particle therapy2025

Cardiac Substructure Dose Reduction and Toxicity Risk Assessment: IMPT Versus IMRT for Breast Cancer.

Lu Cao, Han Zhao, Shujun Zhang, Keman Liao, Mei Chen, Gang Cai, Dan Ou, Jing Yang, Xiaoyu Wu, Huan Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of particle therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lu CaoDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Han ZhaoDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shujun ZhangDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Keman LiaoDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Mei ChenDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Gang CaiDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Dan OuDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jing YangDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiaoyu WuDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Huan LiDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Feifei XuDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Weixiang QiDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yibin ZhangDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jiayi ChenDepartment of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Intensity-modulated proton therapy (IMPT) significantly reduces mean heart dose (MHD), but data on cardiac substructure dose and toxicity compared to intensity-modulated radiation therapy (IMRT) are limited. This study evaluated dose reduction in cardiac substructures between IMPT and IMRT and assessed cardiac toxicity risks using 2 normal tissue complication probability models. Materials and methods: A retrospective analysis was conducted on 30 breast cancer patients from a randomized trial with the highest MHD receiving IMRT. IMPT plans were created for a prescribed dose of 4005 cGy(RBE) in 15 fractions. Normal tissue complication probability models were used to compare individual acute coronary events (ACEs) risk between IMPT and IMRT. Results: Intensity-modulated proton therapy reduced cardiac substructure doses by 63.34% to 100%, with greater absolute reductions in left-sided and relative reductions in right-sided patients. For left-sided internal mammary node irradiation (IMNI), IMPT achieved an 82.25% reduction for left anterior descending coronary artery ( Conclusion: Intensity-modulated proton therapy provides excellent cardiac protection, particularly for left-sided IMNI and high-risk patients.

Indexed as

Cardiac substructuresCardiac toxicityIntensity-modulated proton therapyNormal Tissue Complication Probability modelRadiation dose

Identifiers

PMID40584402
PMCPMC12205686

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.