Evidence map›Paper›PMID 40584397›Full record

SynthesisRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2025

Short cervix and use of cervical pessary for preventing preterm birth in singleton and twin pregnancies: a systematic review and meta-analysis.

Ana Clara Felix de Farias Santos, Nicole Dos Santos Pimenta, Ana Gabriela Alves Pereira, Gabriela Oliveira Gonçalves Molino, Maírla Marina Ferreira Dias, Pedro Henrique Costa Matos da Silva

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana Clara Felix de Farias SantosUniversidade Cidade de São Paulo São PauloSP Brazil Universidade Cidade de São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0004-0007-0866
Nicole Dos Santos PimentaUniversidade Federal do Estado do Rio de Janeiro Rio de JaneiroRJ Brazil Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.ORCID https://orcid.org/0009-0001-4527-8546
Ana Gabriela Alves PereiraUniversidade Estadual Paulista São PauloSP Brazil Universidade Estadual Paulista, São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0003-7023-6254
Gabriela Oliveira Gonçalves MolinoUniversidade Federal de Ciências da Saúde de Porto Alegre Porto AlegreRS Brazil Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0003-2082-2215
Maírla Marina Ferreira DiasUniversidade Federal de Campina Grande Campina GrandePB Brazil Universidade Federal de Campina Grande, Campina Grande, PB, Brazil.ORCID https://orcid.org/0009-0006-1297-7478
Pedro Henrique Costa Matos da SilvaUniversidade Federal de Goiás Department of Gynecologic and Obstetrics GoiâniaGO Brazil Department of Gynecologic and Obstetrics, Universidade Federal de Goiás, Goiânia, GO, Brazil.ORCID https://orcid.org/0000-0002-2707-9324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Preterm birth remains a significant contributor to neonatal morbidity and mortality. The use of cervical pessaries as an intervention for preventing preterm delivery in women with a short cervix has been a subject of interest. We evaluated the effectiveness of cervical pessary compared to standard care in preventing preterm delivery in women with a short cervix. Data source: Databases were systematically searched in PubMed, Cochrane, and Embase databases in December 2023. Study selection: Randomized clinical trials with the outcomes of interest were included. Data collect: We computed risk ratios for binary endpoints, with 95% confidence intervals. Heterogeneity was assessed using I2 statistics. Data were analyzed using R software (version 4.3.0). The primary outcomes of interest were preterm delivery before 37 weeks, and preterm delivery before 34 weeks. Data synthesis: Seventeen studies with 5,704 patients were included. The use of cervical pessary was associated with a decreased risk of preterm delivery before 37 (RR 0.88; 95% CI 0.81-0.96) and 34 weeks (RR 0.79; 95% CI 0.63-0.99) of gestation in twin pregnancies as compared to standard care without progesterone. There were no significant differences in preterm delivery in singleton pregnancy, neonatal outcomes, preterm premature rupture of the membranes or chorioamnionitis. Conclusion: The use of cervical pessary was associated with a significant reduction in preterm delivery at 34 and 37 weeks of gestation in twin pregnancies among patients with a short cervix compared to no treatment. No significant difference was found in singleton pregnancies or maternal outcomes.

Indexed as

Cervix UteriPessariesPremature BirthFemaleHumansPregnancyPregnancy, TwinRandomized Controlled Trials as TopicCervical length measurementPessariesProgesterone, Premature birthShort cervix

Identifiers

PMID40584397
PMCPMC12204114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.