ReviewClinical, cosmetic and investigational dermatology2025
Alopecia Secondary to Hyaluronic Acid Injection: A Case Report and Literature Review.
Review in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Treatment for Filler-Induced Alopecia with Concentrated Growth Factors.Clinical, cosmetic and investigational dermatology · 2026Article
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hyaluronic acid injections, commonly used for anti-aging purposes, carry potential risks, including transient or permanent alopecia, a complication not yet fully characterized. This adverse effect can result from various mechanisms, such as pressure, ischemia, inflammation, and necrosis. Objective: This study aimed to present a case report of a patient treated with Concentrated Growth Factor combined with microneedling and minoxidil for alopecia following hyaluronic acid injection in the left temporal scalp and to systematically review literature from January 2000 to December 2024 on alopecia secondary to hyaluronic acid injections. Methods: A 23-year-old woman developed a 5×6.5 cm alopecic patch on the left temporal scalp just four days after receiving 5 mL of Restylane hyaluronic acid filler in the frontal area. Despite initial treatment with 1500 units of hyaluronidase, alopecia progressed. A multimodal therapy was then initiated, including Concentrated Growth Factor injections, microneedling, and topical 5% minoxidil, delivered over three sessions at 1-2-week intervals. A systematic literature search (PubMed/Web of Science/Embase, 2000-2024) identified 13 relevant articles reporting on 19 cases of hyaluronic acid-induced alopecia for analysis. Results: In the case report, the patient experienced full hair regrowth after treatment with Concentrated Growth Factor, microneedling, and minoxidil. Additionally, thirteen full-text articles involving 19 patients with hyaluronic acid-induced alopecia were analyzed. Data collected included filler type, injection site, complication site, onset of alopecia, associated symptoms, diagnostic tests, proposed mechanisms, treatment approaches, and outcomes. Various treatments were employed across studies, with variable success rates. Conclusion: Prompt diagnosis and early intervention are crucial in preventing irreversible hair loss after HA injections. Knowledge of scalp anatomy and injectable materials is essential. This case suggests that combining Concentrated Growth Factor, microneedling, and minoxidil may offer a promising therapeutic strategy for HA-induced alopecia.
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