ArticleClinical, cosmetic and investigational dermatology2025
Testosterone Deficiency and Sleep Deprivation as Risk Factors for Psoriasis: Insights From the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex Hormones in Psoriatic Disease: A Systematic Review.American journal of clinical dermatology · 2026Pooled it
- Sex hormone-psoriasis interactions: from sex-specific clinical features to immunoregulatory mechanisms.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Psoriasis is a chronic, multisystemic immune-mediated inflammatory disorder with a complex etiology involving genetic, environmental, and systemic factors. Testosterone, a key androgen hormone, has immunomodulatory effects, and its deficiency is linked to increased inflammation. Sleep disturbances are also known to exacerbate systemic inflammation. This study investigates the associations between low testosterone levels, short sleep duration, and psoriasis risk using data from the US National Health and Nutrition Examination Survey (NHANES) 2011-2014. Methods: This cross-sectional study included 4,060 male participants, after excluding individuals with missing data on psoriasis, testosterone, sleep duration, and relevant covariates. Psoriasis status was self-reported, testosterone levels were measured using isotope-dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS), and sleep duration was assessed through a self-reported questionnaire. Multivariable logistic regression models were used to estimate the associations between testosterone levels, sleep duration, and psoriasis risk. Restricted cubic spline (RCS) analysis explored potential non-linear relationships, and subgroup and sensitivity analyses were performed to test the robustness of the findings. Results: Participants with testosterone levels below 300 ng/dL had a significantly higher risk of psoriasis (OR=2.97, 95% CI: 2.16-4.09, P<0.001) in the fully adjusted model. Short sleep duration (<7 hours) was also associated with increased psoriasis risk (OR=1.76, 95% CI: 1.33-2.35, P<0.001). The RCS analysis revealed a non-linear association between both testosterone levels and sleep duration with psoriasis risk, with risk plateauing at extremely low testosterone levels and sleep durations longer than 8 hours. Sensitivity analysis excluding participants with testosterone levels >1000 ng/dL confirmed the robustness of these associations. Conclusion: Low testosterone levels and short sleep duration are independently associated with an increased risk of psoriasis in a large, diverse male population. These findings highlight the importance of hormonal and lifestyle factors in the prevention and management of psoriasis, suggesting potential intervention points for improving patient outcomes.
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