Evidence map›Paper›PMID 40584380›Full record

ArticleACS omega2025

One-Health Approach to Managing Aflatoxin-Producing Aspergillus flavus Using Spent Mushroom Substrate of

Wesley Morais de Araújo, Emanuel Pereira Silva, Gessymara Cainã Sales da Silva, Lívia Soares de França Silva, Francinalva Dantas de Medeiros, José Eduardo Gonçalves, Bruna Braga Dantas, Kelvyn Kennedy de Figueiredo Silva, Anauara Lima E Silva, Josean Fechine Tavares and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wesley Morais de AraújoFungi Research Group, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175-000, Brazil.
Emanuel Pereira SilvaFungi Research Group, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175-000, Brazil.
Gessymara Cainã Sales da SilvaFungi Research Group, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175-000, Brazil.
Lívia Soares de França SilvaFungi Research Group, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175-000, Brazil.
Francinalva Dantas de MedeirosPlanetary Health Research Group, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175-000, Brazil.
José Eduardo GonçalvesCentro de Estudos e Desenvolvimento Analítico Farmacêutico da Faculdade de Farmácia da Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Bruna Braga DantasCurimataú Cancer Observatory, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175000, Brazil.
Kelvyn Kennedy de Figueiredo SilvaCurimataú Cancer Observatory, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175000, Brazil.
Anauara Lima E SilvaGraduate Program in Natural and Synthetic Bioactive Products, Center for Health Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil.
Josean Fechine TavaresGraduate Program in Natural and Synthetic Bioactive Products, Center for Health Sciences, Federal University of Paraíba, João Pessoa 58051-900, Brazil.ORCID https://orcid.org/0000-0003-0293-2605
Jhonatan Rafael Zárate-SalazarGraduate Program Ecology and Conservation, Federal University of Sergipe, São Cristóvão 49100-000, Brazil.ORCID https://orcid.org/0000-0001-9251-5340
Juliana Moura-MendesCentro Multidisciplinario de Investigaciones Tecnológicas, Universidad Nacional de Asunción, San Lorenzo 3492, Paraguay.
Fillipe de Oliveira PereiraFungi Research Group, Academic Unit of Health, Education and Health Center, Federal University of Campina Grande, Cuité 58175-000, Brazil.ORCID https://orcid.org/0000-0002-3081-4174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food loss represents a critical global concern. Aspergillus flavus is central to this issue, contaminating maize crops with aflatoxins. The agricultural fungicide carboxin presents significant challenges due to the rise of resistant fungal strains. This study investigates the antifungal efficacy of spent mushroom substrates from Pleurotus ostreatus (SPoS) and P. djamor (SPdS) cultivated on banana leaves, combined with carboxin (CBX), against A. flavus strains isolated from maize. The SPoS and SPdS extracts showed a low biogenic amine content and a global profile (1H NMR) of volatile oils, unsaturated fatty acids, polysaccharides, oligosaccharides, tannins, and flavonoids. A. flavus strains were not susceptible to amphotericin B and itraconazole. SGPo and SGPd exhibited fungicidal activity against all strains tested, with MIC values ranging from 1024 to 2048 mg/L. CBX demonstrated fungicidal activity with MIC values ranging from 32 to 512 mg/L. No antagonism between CBX+SPdS and CBX+SPoS was observed. SPoS and SPdS showed significant inhibition of conidial germination and mycelial growth, but CBX+SPdS and CBX+SPoS were more potent than individual agents (

Identifiers

PMID40584380
PMCPMC12199071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.