Evidence map›Paper›PMID 40584342›Full record

ArticleACS omega2025

Aging is a Risk Factor for Rheumatoid Arthritis in Rats: Therapeutic Potential of 4‑(Phenylselanyl)-2H-chromen-2-one.

Caren Aline Ramson da Fonseca, Jaini Janke Paltian, Ketlyn Pereira da Motta, Carolina Cristóvão Martins, Jean Carlo Kazmierczak, Ricardo Frederico Schumacher, Mauro Pereira Soares, Cristiane Luchese, Ethel Antunes Wilhelm

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caren Aline Ramson da FonsecaCenter of Chemical, Pharmaceutical and Food Sciences, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas, Pelotas City 96010-900, Brazil.
Jaini Janke PaltianCenter of Chemical, Pharmaceutical and Food Sciences, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas, Pelotas City 96010-900, Brazil.
Ketlyn Pereira da MottaCenter of Chemical, Pharmaceutical and Food Sciences, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas, Pelotas City 96010-900, Brazil.
Carolina Cristóvão MartinsCenter of Chemical, Pharmaceutical and Food Sciences, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas, Pelotas City 96010-900, Brazil.
Jean Carlo KazmierczakChemistry Department, Graduate Program in Chemistry, Federal University of Santa Maria, Santa Maria City 97105-900, Brazil.
Ricardo Frederico SchumacherChemistry Department, Graduate Program in Chemistry, Federal University of Santa Maria, Santa Maria City 97105-900, Brazil.ORCID https://orcid.org/0000-0003-4723-1925
Mauro Pereira SoaresRegional Diagnostic Laboratory, Faculty of Veterinary, Federal University of Pelotas, Pelotas City 96010-900, Brazil.
Cristiane LucheseCenter of Chemical, Pharmaceutical and Food Sciences, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas, Pelotas City 96010-900, Brazil.
Ethel Antunes WilhelmCenter of Chemical, Pharmaceutical and Food Sciences, Graduate Program in Biochemistry and Bioprospecting, Federal University of Pelotas, Pelotas City 96010-900, Brazil.ORCID https://orcid.org/0000-0002-2875-9962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The underlying mechanisms of rheumatoid arthritis (RA) remain inconclusive; nevertheless, several factors may contribute to developing and exacerbating the disease's signs and symptoms. It is well established that the structure and function of the organism decline with age; consequently, the aging process has become a significant risk factor for several human diseases. Thus, the current study investigated aging as a risk factor for RA in rats and the potential of 4-(phenylselanyl)-2H-chromen-2-one (4-PSCO) as a new therapeutic strategy. Arthritis was induced by intraplantar injection (i.pl.) of complete Freund's adjuvant (CFA; 0.1 mL) in the left hind paw of young and aged adult male Wistar rats. The 4-PSCO (1 mg kg

Identifiers

PMID40584342
PMCPMC12198990

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.