Evidence map›Paper›PMID 40584167›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2025

Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models.

Cheng Wang, Leah E Latham, Shuliang Liu, John Talpos, Tucker A Patterson, Joseph P Hanig, Fang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. 2024 international conference on neuroprotective agents conference proceedings.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cheng WangDivision of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, United States.
Leah E LathamDivision of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, United States.
Shuliang LiuDivision of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, United States.
John TalposDivision of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, United States.
Tucker A PattersonOffice of Center Director, National Center for Toxicological Research/Food and Drug Administration (FDA), Jefferson, AR, United States.
Joseph P HanigOffice of Pharmaceutical Quality, Center for Drug Evaluation and Research/FDA, Silver Spring, MD, United States.
Fang LiuDivision of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Safety concerns about general anesthetics (GA), such as desflurane (a commonly used gaseous anesthetic agent), arose from studies documenting neural cell death and behavioral changes after early-life exposure to anesthetics and compounds with related modes of action. Neural stem cells (NSCs) can recapitulate most critical events during central nervous system (CNS) development

Indexed as

Anesthetics, InhalationIsofluraneNeural Stem CellsAnimalsCell DifferentiationCell ProliferationCells, CulturedCell SurvivalDesfluraneAnesthetics, InhalationDesfluraneIsofluraneanestheticsdesflurane,developing neuronsneural differentiationneurotoxicity

Identifiers

PMID40584167
PMCPMC12203245

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.