ArticleVeterinary world2025
A comparative study of collagen morphology and joint strength in anterior cruciate ligament repair and reconstruction models in rabbits.
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Next-generation strategies for anterior cruciate ligament repair: constructing biointelligent ligament grafts integrating biomimetic design, immune modulation, and sensory feedback.Frontiers in bioengineering and biotechnology · 2026Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Anterior cruciate ligament (ACL) repair offers several theoretical advantages over reconstruction, including preservation of native proprioception and reduced donor-site morbidity. However, the current experimental models are predominantly limited to ACL reconstruction, leaving a critical gap in ACL repair research. This study introduces a novel rabbit model to evaluate osteointegration and mechanical strength at the tendon/ligament-bone interface following ACL repair and reconstruction. Materials and Methods: Six male New Zealand White rabbits ( Results: All surgical procedures were completed without complications. Histological analysis showed greater numbers of Sharpey's-like fibers in the reconstruction group (6.33 ± 0.58%) compared to the repair group (5.67 ± 1.6%), though not statistically significant (p > 0.05). Type I collagen fibers were significantly longer in the reconstruction group in both longitudinal (3.10 ± 0.05 μm vs. 2.97 ± 0.04 μm) and transverse (1.94 ± 0.09 μm vs. 1.81 ± 0.05 μm) dimensions (p < 0.05). Type III collagen dimensions did not differ significantly. The mean tensile failure load was higher in the reconstruction group (105.96 ± 63.37 N) than in the repair group (62.56 ± 20.11 N), though this difference was not statistically significant (p > 0.05). Conclusion: This study establishes a reproducible and cost-effective ACL repair model in rabbits and confirms that tendon-bone osteointegration occurs in both ACL repair and reconstruction. Superior biomechanical strength and enhanced type I collagen integration in the reconstruction group underscore current clinical outcomes favoring reconstruction. This model offers a valuable platform for exploring biological augmentation strategies to enhance ACL repair efficacy.
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