Evidence map›Paper›PMID 40583962›Full record

ArticlemicroPublication biology2025

The small regulatory RNA DsrA silences the locus of enterocyte effacement of enteropathogenic

Brian Critelli, Zoe Mrozek, Alexa Mihaita, Lianna Long, Abigail Robinson, Shantanu Bhatt

Abstract read
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Article in microPublication biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian CritelliDepartment of Biology, Saint Joseph's University, 5600 City Avenue, Philadelphia, PA, 19131, United States.
Zoe Mrozek *Department of Biology, Saint Joseph's University, 5600 City Avenue, Philadelphia, PA, 19131, United States.
Alexa Mihaita *Department of Biology, Saint Joseph's University, 5600 City Avenue, Philadelphia, PA, 19131, United States.
Lianna Long *Department of Biology, Saint Joseph's University, 5600 City Avenue, Philadelphia, PA, 19131, United States.
Abigail Robinson *Department of Biology, Saint Joseph's University, 5600 City Avenue, Philadelphia, PA, 19131, United States.
Shantanu BhattDepartment of Biology, Saint Joseph's University, 5600 City Avenue, Philadelphia, PA, 19131, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attaching and effacing (A/E) pathogens adhere to intestinal cells (attachment) and destroy their microvilli (effacement). The A/E pathophenotype is encoded by a cluster of genes that are organized into the pathogenicity island called locus of enterocyte effacement (LEE). While transcriptional regulation of the LEE has been extensively interrogated in A/E pathogens, posttranscriptional regulation remains poorly understood. The RNA-binding protein Hfq and Hfq-dependent regulatory RNAs (sRNAs) play important roles in regulating the LEE posttranscriptionally. In a recent screen, we identified the Hfq-dependent sRNA DsrA as a novel riboregulator of the LEE in the A/E pathogen enteropathogenic

Identifiers

PMID40583962
PMCPMC12205375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.