ArticleBasic and clinical neuroscience
Structural Changes in Pharyngeal and Tongue Muscles as a Potential Contributor to Dysphagia in Alzheimer Disease Rat Model.
Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Alzheimer disease (AD) is a progressive neurodegenerative disease that accounts for 60% of dementia cases worldwide. Despite the lack of concrete information about the prevalence of dysphagia among AD patients, it still significantly impairs their quality of life (QoL). That outcome necessitates more investigations to understand the pathophysiology of this condition and how to manage it. In this study, we examined if AD-associated changes in pharyngeal and tongue muscles could explain dysphagia. Methods: Fourteen adult male rats were allocated into 2 groups: Group I (control) received distilled water orally, group II (AD) received aluminum chloride (AlCl Results: Our AD model showed marked cognitive impairment, hippocampal oxidative stress, and increased brain Aβ expression (P=0.0003) compared to controls. Dysphagia was confirmed by loss of body weight (P=0.0077) and decreased eating and drinking patterns by 25%-35% in AD versus the control group. Histopathological, immune-histochemical, and biochemical evidence, including increased levels of pharyngeal Aβ (P=0.0017), were detected in AD rats' tongue and pharyngeal muscles. Conclusion: Dysphagia in AD can result not only centrally but also due to local involvement of the tongue and pharynx. Further translational studies linking dysphagia to AD pathology will be needed.
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