Evidence map›Paper›PMID 40583854›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Theranostic Toolbox for Neutrophil Functionalization.

Pascal Bouvain, Kay-Matthias Thomy, Anika Maria Prinz, Bodo Steckel, Shiwa Kadir, Alexandra Röhs, Jonas Schmitz, Claudia Dohle, Matthias Karg, Maria Grandoch and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. TargetedImmunotherapy advances · 2026
    Review
  2. Theranostic Toolbox for Neutrophil Functionalization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pascal BouvainExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Kay-Matthias ThomyExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Anika Maria PrinzInstitute for Translational Pharmacology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Bodo SteckelExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Shiwa KadirExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Alexandra RöhsExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Jonas SchmitzInstitute of Physical Chemistry 1, Heinrich Heine University, 40225, Düsseldorf, Germany.
Claudia DohleDepartment of Anesthesiology, University Hospital Düsseldorf, 40225, Düsseldorf, Germany.
Matthias KargInstitute of Physical Chemistry 1, Heinrich Heine University, 40225, Düsseldorf, Germany.
Maria GrandochInstitute for Translational Pharmacology, Heinrich Heine University, 40225, Düsseldorf, Germany.
Ulrich FlögelExperimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.ORCID https://orcid.org/0000-0001-7181-4392
Sebastian TemmeDepartment of Anesthesiology, University Hospital Düsseldorf, 40225, Düsseldorf, Germany.

Funding

Deutsche Forschungsgemeinschaft CRC 259Deutsche Forschungsgemeinschaft FL303/6-1/2Deutsche Forschungsgemeinschaft INST208/749-1FUGGDeutsche Forschungsgemeinschaft INST208/764-1FUGGDeutsche Forschungsgemeinschaft TE1209/1-1/2
6 · The paper itself

Abstract

Neutrophils are crucial for fighting invading pathogens and for the clearance of sterile wounds. However, in cases of overwhelming pathogens or excessive inflammatory responses, fine-tuning of neutrophil functions can help to either enhance bacterial killing or prevent unwanted tissue damage. Thus, the present study is aimed at developing a nanoparticle-based toolbox to direct neutrophils toward either a proinflammatory or reparative phenotype tailored to the specific inflammatory environment. For this, neutrophil-specific fluorine nanoparticles additionally equipped with either activating or inhibiting peptides for a background-free

Indexed as

NanoparticlesNeutrophilsTheranostic NanomedicineAnimalsHumansMagnetic Resonance ImagingMiceMice, Inbred C57BLfluorineinflammationMRIneutrophilstargeted nanoparticlestheranostics

Identifiers

PMID40583854
PMCPMC12442632

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.