ArticleHead & neck2025
Post-Thyroidectomy Opioid Prescription and Risk of Persistent Opioid Use: A Propensity Matched Cohort Study.
Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluates the risk of persistent opioid use (POU) among thyroidectomy patients given postoperative opioids.
methodsPatients undergoing thyroidectomy were identified using the TriNetX Research Platform (2010-2024). Cohorts were divided based on opioid prescriptions on the day of surgery. With propensity score matching to prevent confounding bias, risk ratios were calculated for opioid prescriptions 3-9 months post-surgery. Secondary outcomes included ED presentation, pain diagnosis, and lifetime risk of opioid use disorder, defined as significant social dysfunction due to uncontrolled use.
resultsThe post-match opioid group (n = 19,727) experienced a 4.61% risk of POU (control: 4.07%), representing a 14% higher risk of POU compared to the non-opioid group (RR 1.14, 95% CI: [1.03, 1.25]). Opioids slightly decreased the likelihood of outpatient visits at 30 days (RR: 0.97 [0.95, 0.98]) and 90 days (RR: 0.96 [0.94, 0.97]) following surgery. There were no significant differences in ED presentation, pain diagnoses at 30 and 90 days, or lifetime OUD risk.
conclusionPost-thyroidectomy opioid prescription modestly increases POU risk, highlighting the need for careful patient counseling and judicious use.
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