Evidence map›Paper›PMID 40583784›Full record

ReviewScience progress

Bacterial lysates in allergic rhinitis and chronic rhinosinusitis: Mechanisms and clinical evidence.

Xinyu Huang, Xu Zhang, Zhiqiang Zhang, Mengyuan Liu, Daoming Bai, Rui Yang, Chunping Yang

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07460934 (Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis - EPCCOR Study), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07460934 nacompletednot on this map

Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis - EPCCOR Study

TypeinterventionalSponsorPleuran, s.r.o.Ran2022 to 2025Enrolled85ConditionsChronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic ProphylaxisArmsImunoglukan P4H® capsules
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyu HuangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID 0009-0003-1085-4501
Xu ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID 0009-0009-3257-1012
Zhiqiang ZhangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Mengyuan LiuDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID 0009-0005-6951-1161
Daoming BaiDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID 0009-0009-7956-686X
Rui YangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.ORCID 0009-0002-7407-8946
Chunping YangDepartment of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are chronic inflammatory disorders of the upper airways with rising global prevalence, contributing significantly to health and socioeconomic burdens. Conventional treatments-including glucocorticoids, antibiotics, antihistamines, and leukotriene inhibitors-remain insufficient in targeting the underlying pathophysiology. Bacterial lysates (BLs), functioning as immunomodulators, activate both innate, and adaptive immune pathways, reestablish Th1/Th2 equilibrium, lower immunoglobulin E concentrations, and attenuate Th2-mediated inflammation. Emerging evidence indicates that BLs (e.g. OM-85, Broncho-Vaxom) markedly improve total nasal symptom scores in AR, suppress Th2 cytokine (IL-4 and IL-13) secretion, and reduce recurrence rates and surgical interventions in CRS. In conjunction with standard therapies, BLs enhance mucosal immune defense and contribute to sustained clinical efficacy. Following the Scale for the Assessment of Narrative Review Articles guidelines, this review critically evaluates the composition, manufacturing processes, immunoregulatory mechanisms, and clinical progress of BLs in AR and CRS, providing a conceptual framework for their clinical application.

Indexed as

Cell ExtractsRhinitisRhinitis, AllergicSinusitisAnimalsBacterial LysatesChronic DiseaseHumansRhinosinusitisTh2 CellsBacterial LysatesBroncho-VaxomCell Extractsallergic rhinitisBacterial lysateschronic rhinosinusitisimmunomodulation

Identifiers

PMID40583784
PMCPMC12214346

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.