Evidence map›Paper›PMID 40583759›Full record

ArticleJournal of empirical research on human research ethics : JERHRE2025

Health Research Ethics in Southern Africa: Building Capacity and Cultivating Excellence.

Zaynab Essack, Paul Ndebele, Heidi Matisonn, Jantina de Vries, Keymanthri Moodley, Stuart Rennie, Joseph Ali, Nancy Kass, Carel IJsselmuiden, Nhlanhla Mkhize and 4 more

Abstract read
In one paragraph

Article in Journal of empirical research on human research ethics : JERHRE, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Impacts of Responsible Conduct of Research Education on the Career and Practice of Graduating Fellows.Journal of empirical research on human research ethics : JERHRE · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zaynab EssackSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.ORCID 0000-0002-8867-3415
Paul NdebeleDepartment of Global Health, Milken Institute School of Public Health, George Washington University, Washington DC, USA.ORCID 0000-0001-9669-1544
Heidi MatisonnSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Jantina de VriesThe EthicsLab, Department of Medicine, University of Cape Town, Rondebosch, Western Cape, South Africa.ORCID 0000-0001-7192-2633
Keymanthri MoodleyDivision of Medical Ethics and Law, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stuart RennieDepartment of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3844-972X
Joseph AliBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-4767-2512
Nancy KassBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Carel IJsselmuidenSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.ORCID 0000-0002-8898-1135
Nhlanhla MkhizeSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Mariana KrugerSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.ORCID 0000-0002-6838-0180
Ann StrodeSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Warren FreedmanSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.
Douglas WassenaarSouth African Research Ethics Training Initiative (SARETI), School of Applied Human Sciences, University of KwaZulu-Natal, Pietermaritzburg, South Africa.ORCID 0000-0003-0839-9231

Funding

The Addis Ababa University-Johns Hopkins University Research Ethics Training Program in Ethiopia (AAU-JHU RETP)R25TW001604 · FIC · JOHNS HOPKINS UNIVERSITY · PI Adamu Addissie, Joseph Ali · 2000 to 2026
$6.4M
SOUTHERN AFRICAN RESEARCH ETHICS TRAINING INITIATIVER25TW001599 · FIC · UNIVERSITY OF PRETORIA · PI ESSACK, ZAYNAB, STRODE, ANN ELAINE · 2000 to 2025
$4.7M
Strengthening Bioethics Capacity and Justice in HealthR25TW007098 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BEHETS, FRIEDA M., RENNIE, STUART · 2004 to 2017
$3.3M
ARESA - Advancing Research Ethics training in Southern AfricaR25TW008981 · FIC · STELLENBOSCH UNIVERSITY · PI MOODLEY, KEYMANTHRI · 2011 to 2015
$1.2M
Establishing an MSc in Global Health Ethics at the University of Cape TownR25TW012219 · FIC · UNIVERSITY OF CAPE TOWN · PI Jantina De Vries · 2022 to 2026
$1.1M
US-Zimbabwe Research Ethics Training Program (US-Zim RETP)R25TW012713 · FIC · GEORGE WASHINGTON UNIVERSITY · PI MIDION MAPFUMO CHIDZONGA, Paul Ndebele · 2024 to 2026
$736k
A community-based adaptation of a peer-led intervention to address alcohol use and HIV risk in pregnant women in South Africa (Mentor Moms+)R34AA030942 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Zaynab Essack, DVORA Leah JOSEPH DAVEY · 2024 to 2026
$524k
FIC NIH HHS R25 TW001599FIC NIH HHS R25 TW001604FIC NIH HHS R25 TW007098FIC NIH HHS R25 TW008981FIC NIH HHS R25 TW012219FIC NIH HHS R25 TW012713NIAAA NIH HHS R34 AA030942
6 · The paper itself

Abstract

The health research landscape in southern Africa is becoming increasingly complex as research efforts intensify to address the region's significant disease burden. The increasing volume and complexity of health research in low- and middle-income countries (LMICs) highlights the ongoing need for enhanced research ethics capacity. To supplement a review published in 2014, this paper provides an overview of research ethics capacity-building initiatives supported through substantive long-term competitive awards from the Fogarty International Center of the US National Institutes of Health between 2014 and 2024. These programs aimed to enhance the capabilities of research ethics committees (RECs) and strengthen research ethics capacity throughout Southern Africa, with broader benefits to the African continent and globally as collaborative health research increases. The programs have successfully developed and delivered comprehensive research ethics curricula tailored to research ethics concerns in the region. Trainees and graduates include clinicians, researchers, REC members, REC administrators, lawyers, and ethicists, with focused efforts to ensure gender parity. This increased representivity of scholars has improved the membership on RECs and in skilled research ethics leadership in the region. For the benefit of future planning, this paper also describes some of the many challenges faced in delivering on program goals - including COVID-19. We also describe innovative solutions developed to address these challenges and meet the needs of students, faculty and institutions, while cultivating excellence in health research ethics. The paper concludes by highlighting areas for future research, underscoring the importance of continued diverse global investment in research ethics capacity to protect research participants and maintain and improve ethical standards and practice in health research within the region and globally. This will enable the development of innovative evidence-based global health solutions based on ethical research.

Indexed as

Bioethicsdeveloping countriesethics education& RCRresearch ethicsresearch ethics committee/IRB review

Identifiers

PMID40583759
PMCPMC12371220

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.