ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2025
[Molecular targeted therapy for progressive low-grade gliomas in children].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
objectivesTo evaluate the efficacy of molecular targeted agents in children with progressive pediatric low-grade gliomas (pLGG).
methodsA retrospective analysis was conducted on pLGG patients treated with oral targeted therapies at the Department of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, from July 2021. Treatment responses and safety profiles were assessed.
resultsAmong the 20 enrolled patients, the trametinib group (
conclusionsMolecular targeted therapy demonstrates clinical efficacy with favorable tolerability in pLGG. Vemurafenib achieves high response rates and induces early tumor shrinkage in patients with
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