Trial reportPsychological medicine2025
A 6-month supported online program for the treatment of persecutory delusions: Feeling Safer.
Trial report in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Do Psychological Interventions Reduce Paranoia in Adolescents? A Systematic Review.Clinical child and family psychology review · 2026Review
- An excitement building in the development of psychological treatments for schizophrenia.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Helping Patients With Persecutory Delusions Find Safety.Schizophrenia bulletin · 2026Article
- Computerised adaptive testing across the paranoia continuum.BMJ mental health · 2025Article
- A counterweight model for understanding and treating persecutory delusions.Psychological medicine · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundBased on an efficacious face-to-face theory-driven psychological therapy for persecutory delusions in the context of psychosis, we set out to develop a scalable guided 6-month online program. The aim was an intervention that patients can easily access and use, produces large clinical effects, and can be supported by a range of mental health professionals in less contact time than face-to-face therapy. We report here the proof-of-concept testing. At least moderate-sized clinical effects were required to progress to a randomized controlled trial (RCT).
methodsIn the 6-month Feeling Safer online program, a certified medical device, patients complete a brief assessment and then are provided with up to 10 modules that match their difficulties. Regular remote meetings with a mental health professional also take place. These may be supplemented by in-person visits. A pre- to post-treatment cohort trial was conducted with 14 patients with persistent persecutory delusions. The primary outcome was the Psychotic Symptoms Rating Scale (PSYRATS)-Delusions.
resultsSatisfaction and usability ratings of the program were high. Very large reductions in persecutory delusions were observed (PSYRATS mean reduction = 7.1, 95% C.I. = 3.4, 10.8,
conclusionsThe clinical effects associated with Feeling Safer were very high, comparable to those seen in the evaluations of the face-to-face therapy, and enable progression to an RCT.
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