ReviewAdvanced healthcare materials2025
Multifunctional Biomedical Devices with Closed-Loop Systems for Precision Therapy.
Review in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- 4D nanoimaging-guided smart therapeutics: spatiotemporal control of disease microenvironments.RSC advances · 2026Review
- Nanomaterial -enabled flexible sensors for continuous biomedical monitoring and closed-loop intervention.Discover nano · 2026Review
- Nanoparticle-Enabled Biomaterials for Controlled Drug Delivery in Implantable and Wearable Devices.International journal of molecular sciences · 2026Review
- Advanced Drug Delivery Strategies in Geriatric Patients with Polypharmacy: Integrating Pharmacokinetics, Personalized Medicine, and Emerging Technologies.Journal of clinical medicine · 2026Review
- Seamless Human-Computer Interaction Enabled by Wearable Biointerfaces and Intelligent Systems.Biomimetics (Basel, Switzerland) · 2026Review
- The biological clock in parkinson's disease: mechanisms and chronotherapy.NPJ Parkinson's disease · 2026Review
- Closing the loop on glioblastoma: A roadmap toward developing bioelectronics for continuous monitoring of tumor state.APL bioengineering · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Electrochemical modulation of host-microbe dynamics in wound healing.Frontiers in microbiology · 2026Review
- Autonomous Microrobots for Spatiotemporally Active Therapeutic Delivery and Controlled Release.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Translating physical stress into biological signals: precision electro-oncology based on conformational changes of electro-sensitive receptors and parameterized immune remodeling.Frontiers in oncology · 2026Review
- Multifunctional Biomedical Devices with Closed-Loop Systems for Precision Therapy.Advanced healthcare materials · 2025Review
- Artificial Intelligence-Powered Nanosensor Platforms for Non-Invasive Breathomic Diagnostics.Nanotechnology, science and applications · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Closed-loop control systems have emerged as transformative tools in precision therapy, enabling real-time monitoring of patient's physiological conditions and automatically adjusting treatments based on direct feedback. By seamlessly integrating sensing feedback and on-demand therapeutic interventions, these systems offer enhanced accuracy, adaptability, and effectiveness, while reducing the risks of over- or under-treatment. This review categorizes closed-loop devices into two major types: self-sustained and externally triggered. It first examines the stimuli-responsive materials and mechanisms essential for self-sustained systems, which autonomously deliver therapeutic agents in response to physiological or environmental cues without external intervention, an approach that is particularly advantageous for managing chronic diseases. The discussion then focuses on recent developments in integrated bioelectronics as a platform for externally triggered closed-loop systems, summarising key innovations in biosensing technologies, personalized therapeutic strategies, and data-driven control algorithms. Finally, the review outlines current challenges and highlights potential research avenues, illustrating the transformative potential of closed-loop systems in a range of precision therapies, including diabetes management and neurostimulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.