Evidence map›Paper›PMID 40583498›Full record

ArticleEuropean journal of heart failure2025

Acute dyspnoea in cancer patients: Prevalence of acute heart failure, resource use and diagnostic accuracy of natriuretic peptides.

Paolo Bima, Desirée Wussler, Pedro Lopez-Ayala, Maria Belkin, Albina Nowak, Xueting Lin, Ivo Strebel, Fabiana Sgueglia, Eleni Michou, Androniki Papachristou and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Paolo Bima *Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0003-2193-0509
Desirée Wussler *Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Pedro Lopez-Ayala *Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Maria BelkinCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Albina NowakDepartment of Endocrinology and Clinical Nutrition, University Hospital Zürich, Zürich, Switzerland.
Xueting LinCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Ivo StrebelCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Fabiana SguegliaCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Eleni MichouCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Androniki PapachristouCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Laureve CholletCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Codruta PopescuCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Nikola KozhuharovCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Samyut ShresthaCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Gabriela KusterCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Katharina RentschLaboratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
Arnold Von EckardsteinLaboratory Medicine, University Hospital Zürich, University of Zürich, Zürich, Switzerland.
Mascha BinderDepartment of Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
Felix MahfoudCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Tobias BreidthardtCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
Christian MuellerCardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.

Funding

Schweizerische Herzstiftung FF23062
6 · The paper itself

Abstract

aimsAmong cancer patients presenting with acute dyspnoea, the prevalence of acute heart failure (AHF), resource use and diagnostic accuracy of natriuretic peptides remain unknown. This study aimed to address these knowledge gaps. METHODS AND

resultsPatients presenting with acute dyspnoea to the emergency department (ED) were prospectively enrolled in a multicentre diagnostic study. AHF was centrally adjudicated by two independent cardiologists based on current guidelines. B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) concentrations were measured at ED presentation. Cancer status, resource use, and long-term outcomes were prospectively assessed. Among 2153 patients, 473 (22.0%) had an active or past cancer. AHF was the most common final diagnosis in both cancer and non-cancer patients (44.4% vs. 51.0%, p = 0.01). Among the alternative diagnoses, pneumonia and cancer-related dyspnoea were more frequent in patients with cancer, while anxiety disorder/hyperventilation was frequent in patients without cancer. Hospitalization rate and length of hospital stay were both higher in cancer patients (p < 0.01). Among AHF-related signs, rales and pleural effusion showed a significant interaction with cancer status and had lower diagnostic accuracy in cancer patients. The area under the curve (AUC) of NT-proBNP was lower in cancer than in non-cancer patients (0.89 vs. 0.93, p = 0.01), while that of BNP was similar (0.93 vs. 0.95, p = ns). This difference was mainly due to active cancers.

conclusionsAcute heart failure was the most common diagnosis in cancer patients presenting with acute dyspnoea. Rales, pleural effusion, and NT-proBNP had lower diagnostic accuracy versus patients without cancer, while that of BNP remained robust.

Indexed as

DyspneaHealth ResourcesHeart FailureNatriuretic Peptide, BrainNeoplasmsPeptide FragmentsAcute DiseaseAgedAged, 80 and overBiomarkersEmergency Service, HospitalFemaleHumansMaleMiddle AgedPrevalenceBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Acute heart failureBiomarkersCancer survivorshipDiagnosisNatriuretic peptides

Identifiers

PMID40583498
PMCPMC12765039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.