Evidence map›Paper›PMID 40583465›Full record

ArticleRadiation research2025

Anti-Tumor Immunization Efficacy after Particle-Radiation Exposure.

Brian Ponnaiya, Naresh T Deoli, Guy Garty, Andrew D Harken, Peter W Grabham, Sally A Amundson, Elizabeth M C Hillman, David J Brenner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian PonnaiyaCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Naresh T DeoliCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Guy GartyCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Andrew D HarkenCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Peter W GrabhamCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Sally A AmundsonCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.
Elizabeth M C HillmanLaboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Zuckerman Mind Brain Behavior Institute and Kavli Institute for Brain Sciences, Columbia University, New York, New York.
David J BrennerCenter for Radiological Research, Columbia University Irving Medical Center, New York, New York.

Funding

Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORNACE, ALBERT J · 2005 to 2024
$105.4M
Flexible Tools for Pre-Clinical Studies to Answer Key Questions UnderlyingHeavy-Ion RadiotherapyU01CA236554 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRENNER, DAVID JONATHAN, HILLMAN, ELIZABETH M. C. · 2019 to 2022
$2.6M
NCI NIH HHS U01 CA236554NIAID NIH HHS U19 AI067773
6 · The paper itself

Abstract

Particle radiotherapy is successful in treating cancers that are typically refractory to conventional low-LET therapy; however, the underlying molecular mechanisms remain largely unknown. Some suggest that, in addition to local tumor control, particle radiotherapy may induce long-range systemic anti-cancer effects involving the immune system that may be responsible for the overall success of the modality. Using previously published methodology, we have assessed anti-tumor responses in vivo using an immunization model. Comparing the efficacy of tumor cells killed by X rays and high-LET ions to protect against subsequent tumor challenge in mice, we have observed that at equidoses, heavy ions are more effective at generating anti-tumor responses than X rays.

Indexed as

ImmunizationNeoplasmsAnimalsCell Line, TumorFemaleMiceX-Rays

Identifiers

PMID40583465
PMCPMC12603923

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.