Evidence map›Paper›PMID 40583410›Full record

ArticleAdvanced healthcare materials2025

Multienzyme (3-in-1)-Mimicking a Single Nucleobase-Derived Bionanozyme for Versatile Environmental and Biomedical Applications.

Subrat Vishwakarma, Om Shanker Tiwari, Durba Banerjee, Linda J W Shimon, Amit Israelstam, Ilia Kaminker, Sudip Mukherjee, Ehud Gazit, Pandeeswar Makam

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Subrat VishwakarmaDepartment of Chemistry, Indian Institute of Technology (BHU), Varanasi, UP, 221005, India.
Om Shanker TiwariThe Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.ORCID https://orcid.org/0000-0002-5918-3281
Durba BanerjeeSchool of Biomedical Engineering, Indian Institute of Technology (BHU), Varanasi, UP, 221005, India.
Linda J W ShimonDepartment of Chemical Research Support, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Amit IsraelstamSchool of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
Ilia KaminkerSchool of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.
Sudip MukherjeeSchool of Biomedical Engineering, Indian Institute of Technology (BHU), Varanasi, UP, 221005, India.
Ehud GazitThe Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.ORCID https://orcid.org/0000-0001-5764-1720
Pandeeswar MakamDepartment of Chemistry, Indian Institute of Technology (BHU), Varanasi, UP, 221005, India.

Funding

Air Force Office of Scientific Research FA8655-21-1-7004ICMR, India IIRPSG-2024-01-03827Indian Institute of Technology (BHU) Varanasi (BHU)/Budget/2021-22/19-(01)/9221)
6 · The paper itself

Abstract

The quest for efficient, robust, and sustainable solutions in environmental remediation and advanced biosensing has catalyzed significant interest in biomimetic enzymology. Here, a new Bionanozyme, synthesized from a single nucleobase-adenine (A)-coordinated with copper (Cu) in a 2D crystalline structure (A-Cu), is presented. This state-of-the-art A-Cu Bionanozyme, inspired by natural redox enzymes (Laccase (LAC), Catechol oxidase (CO), and Peroxidase (POD)), is synthesized via simple and scalable, green methods including solvent-free co-grinding and natural aqueous evaporation process. A-Cu's unique structure exhibits triple-enzyme-mimicking catalytic activity, enabling it to detect and degrade toxic phenols in contaminated water and perform ultrasensitive colorimetric biosensing for key biomarkers like dopamine, hydrogen peroxide, and glutathione. Additionally, its biocompatibility and reactive oxygen species (ROS) scavenging properties highlight its potential in biomedical applications. Hence, this report provides a foundational framework for developing next-generation multienzyme-mimicking Bionanozymes with the potential to enhance eco-friendly technologies in both environmental and biomedical applications.

Indexed as

Biomimetic MaterialsBiosensing TechniquesAdenineCatechol OxidaseCopperDopamineHydrogen PeroxideLaccasePeroxidaseReactive Oxygen SpeciesAdenineCatechol OxidaseCopperDopamineHydrogen PeroxideLaccasePeroxidaseReactive Oxygen Speciesbiomedical applicationsBionanozymeenzymesupramolecular assemblies

Identifiers

PMID40583410
PMCPMC12447034

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.