ReviewImmunotherapy2025
NKT cells-a generalist in disease treatment and a new key to unlock immunotherapy.
Review in Immunotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NKT cells (natural killer T cells) are a subpopulation of specialized T cells that recognize lipid antigens presented by CD1d molecules, which can be classified into type I NKT cells, type II NKT cells and NKT-like cells. NKT cells play a key role in linking innate and adaptive immunity. In recent years, NKT cells have been found to be involved in the development of various systemic diseases, including tumors, respiratory system diseases, autoimmune diseases, reproductive system diseases, gastrointestinal system diseases and liver diseases. Thus, immunotherapy targeting NKT cells has brought novel strategies for the treatment of cancers and other diseases. Currently, NKT cell-based immunotherapy includes NKT cell agonist, CAR-NKT and NKT gene editing. Among them, α-galactosylceramide (α-GalCer), a NKT cell agonist, has demonstrated promising applications in enhancing vaccine immunogenicity and anti-tumor immunity. In conclusion, this review systematically summarizes the development, differentiation, classification, and function of NKT cells, as well as their relationships with systemic diseases. Additionally, this review also emphasizes the prospects for the clinical application of NKT cell-based immunotherapy. Future research should focus on the development of novel NKT cell-targeted therapeutic strategies and vaccine adjuvants to advance personalized medicine and precision immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.