Evidence map›Paper›PMID 40583382›Full record

ArticleAdvanced healthcare materials2025

Interstitial N-Strengthened Copper-Based Bioactive Conductive Dressings Combined with Electromagnetic Fields for Enhanced Wound Healing.

Xiaohui Qiu, Xianrui Wu, Shaohua Wang, Jie Gu, Senhao Ying, Jiaohao Mo, Chen Jing, Huiliang Cao, Zhongchang Wang, Jianda Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaohui QiuDepartment of Plastic and Reconstructive Surgery, Xiangya III Hospital of Central South University, Changsha, 410008, China.ORCID https://orcid.org/0000-0001-6710-9869
Xianrui WuDepartment of Plastic and Reconstructive Surgery, Xiangya III Hospital of Central South University, Changsha, 410008, China.
Shaohua WangDepartment of Plastic and Reconstructive Surgery, Xiangya III Hospital of Central South University, Changsha, 410008, China.
Jie GuMartini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251, Hamburg, Germany.
Senhao YingCollege of Mechanical Engineering, Key Laboratory of Hunan Province of Equipment Safety Service Technology Under Extreme Environment, University of South China, Hengyang, Hunan Province, 421001, China.
Jiaohao MoCollege of Mechanical Engineering, Key Laboratory of Hunan Province of Equipment Safety Service Technology Under Extreme Environment, University of South China, Hengyang, Hunan Province, 421001, China.
Chen JingDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Huiliang CaoSchool of Materials Engineering, Donghua University of Technology, Shanghai, 201620, China.
Zhongchang WangSchool of Materials Science and Engineering, Beijing University of Aeronautics and Astronautics, Beijing, 100083, China.
Jianda ZhouDepartment of Plastic and Reconstructive Surgery, Xiangya III Hospital of Central South University, Changsha, 410008, China.

Funding

Fundamental Research Funds for the Central Universities of Central South University 2024ZZTS0177FuRong Laboratory, Changsha 2023SK2115FuRong Laboratory, Changsha 410078Hunan Provincial Postgraduate Research and Innovation Project CX20240329Hunan Provincial Science and Technology Innovation Plan 2021sk53714National Natural Science Foundation of China 52305313
6 · The paper itself

Abstract

This study introduces an innovative design and application of a nitrogen-interstitially strengthened Cu-Fe-Zn alloy bioactive dressing, which combines intrinsic bioactivity with electromagnetic stimulation to significantly accelerate wound healing. Interstitial nitrogen solid-solution Cu-Fe-Zn alloys were fabricated by integrating a low-oxygen controlled powder sintering process (N2(10%)/Ar (90%) atmosphere). Subsequent cold drawing generated ultrafine alloy wires (0.04 ± 0.005 mm) with a tensile strength of 1120 MPa, representing a 20.37% enhancement compared with conventional approaches. Utilizing an intelligent jacquard textile system, these Cu-Fe-Zn alloy wires and cotton yarn were woven into coaxial circular dressings tailored to wound morphology, allowing controlled directional current flow while exhibiting excellent biocompatibility and antibacterial properties. A customized electromagnetic coupling system, consisting of an electromagnetic field generator and Helmholtz coils, was developed. Integration with bioactive dressings resulted in a precise, multifunctional therapeutic platform. Electromagnetic stimulation achieved dual therapeutic outcomes: (1) activating the VEGF/p38-HSP27 signaling pathway, significantly enhancing angiogenesis (2.1-fold compared with controls) and promoting M2 macrophage polarization (+25.6%), thereby accelerating tissue regeneration; and (2) inhibiting the IL-17/NF-κB signaling axis, reducing TNF-α expression by 68%, thus effectively suppressing inflammation. This study offers essential technical insights for developing next-generation intelligent electromagnetic wound healing systems with substantial clinical potential.

Indexed as

BandagesBiocompatible MaterialsCopperElectromagnetic FieldsNitrogenWound HealingAlloysAnimalsHumansMacrophagesMiceVascular Endothelial Growth Factor AAlloysBiocompatible MaterialsCopperNitrogenVascular Endothelial Growth Factor Aangiogenesisanti‐inflammatorycopper alloy dressing combined with electromagnetic field synergistic therapy (EMFST)IL‐17 pathwayp38 pathwayrefractory wound healing

Identifiers

PMID40583382
PMCPMC12447041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.