Evidence map›Paper›PMID 40583369›Full record

ArticleHead & neck2025

Health-Related Quality of Life in Patients With a Head and Neck Sarcoma: A Mixed-Methods Study.

E Koffi, C S Padilla, C Drabbe, W H Schreuder, C Zemouri, D den Hollander, D J Grünhagen, S Sodergren, S Singer, R L Jones and 16 more

Abstract read
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

E KoffiVrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0009-0002-4670-0259
C S PadillaDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
C DrabbeDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
W H SchreuderDepartment of Head and Neck Surgery and Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
C ZemouriZemouri et al., Public Health Research, Amsterdam, the Netherlands.
D den HollanderDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
D J GrünhagenDepartment of Surgical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
S SodergrenSchool of Health Sciences, University of Southampton, Southampton, UK.
S SingerInstitute of Medical Biostatistics, Epidemiology, and Informatics, University Medical Centre Mainz, Mainz, Germany.ORCID 0000-0001-5784-7964
R L JonesSarcoma Unit, Royal Marsden Hospital and Institute of Cancer Research, London, UK.
I M E DesarDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
L FauskeDepartment of Oncology, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
M PintoRehabilitation Medicine Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Naples, Italy.
I NixonBeatson Cancer Center, Glasgow, UK.
S SalahAdult Medical Oncology Department, King Fahad Specialist Hospital-Dammam, Dammam, Saudi Arabia.
Ø S BrulandDepartment of Oncology, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
V L M N SoomersDepartment of Medical Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
M A J van de SandeDepartment of Orthopedics, Leiden University Medical Center, Leiden, the Netherlands.
J J de HaanDepartment of Medical Oncology, University Medical Center Groningen, Groningen, the Netherlands.
C VerhoefDepartment of Surgical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
L C StegginkDepartment of Medical Oncology, Maastricht University Medical Centre, Maastricht, the Netherlands.
W J van HoudtDepartment of Surgical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
T I BootsmaDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
M T TesselaarDepartment of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
W T A van der GraafDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
O HussonDepartment of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Funding

European Organisation for Research and Treatment of Cancer
6 · The paper itself

Abstract

backgroundPatients with head and neck sarcomas (HNS) face unique health-related quality of life (HRQoL) challenges due to its disease rarity. This study examined and identified the prevalence of generic- and location-specific HRQoL issues.

methodsQuantitative data from 72 HNS survivors (SURVSARC study), and qualitative data from 18 HNS patients (EORTC QoL VOICE study) were examined. Descriptive statistics was used for questionnaire data. Qualitative data was thematically analyzed.

resultsQuantitative findings showed fatigue (68%), speaking issues (50%), and dry mouth (48%) as common problems. Qualitative findings supported quantitative results and highlighted HNS-specific issues, including throat pain, impaired tongue mobility, and swelling in the face and neck.

conclusionHNS patients share symptoms with other cancers, but location-specific issues, such as lack of tongue mobility, require tailored measurement strategies. Combining generic (EORTC QLQ-C30), location-specific (EORTC QLQ-H&N43) questionnaires, and an HNS-specific item list provides a comprehensive HRQoL assessment for future research and clinical practice.

Indexed as

Head and Neck NeoplasmsQuality of LifeSarcomaAdultAgedFemaleHumansMaleMiddle AgedSurveys and Questionnaireshead and neckhealth‐related quality of lifemixed‐method studyrare cancersarcomas

Identifiers

PMID40583369
PMCPMC12541677

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.