ArticleMovement disorders : official journal of the Movement Disorder Society2025
Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A Network Centered on the Visual-Motor Cortex Is Critically Involved in Postural Abnormality in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
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11 authors.
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Abstract
backgroundStudies on brain connectivity offer important insights into the changes that occur in central network diseases such as Parkinson's disease (PD). Camptocormia, a condition characterized by abnormal flexion of the trunk, often occurs in advanced PD, but its underlying mechanisms are not yet clear.
objectiveThis study aims to investigate the changes in the central motor network, associated with camptocormia.
methodsHigh-density 256-channel electroencephalography (EEG) and multichannel electromyography (EMG) recordings from the paravertebral lumbar (PVL) muscles were obtained. Tomographic maps of EEG-EMG coherence were obtained using a beamformer algorithm based on individual β frequencies. We employed temporal partial directed coherence analyses to estimate the direction of information flow between coherent sources.
resultsIn all patients and healthy controls, we found a widespread central network that showed coherence with PVL muscles and consisted of cortical and subcortical regions mostly with mutual interactions on the central level and with the paravertebral muscles. In camptocormia patients, there was a significantly stronger coherence between the cortical and muscle activity than in PD without camptocormia patients. Brainstem activation was absent in camptocormia patients, whereas in PD without camptocormia patients, coherent activation in the posterior parietal cortex was missing.
conclusionIncreased central muscle drive to the paravertebral muscles in camptocormia patients may indicate a relatively simple compensatory strategy to overcome stooped posture, whereas the decreased interaction strength between the central coherent sources and the lack of brainstem involvement likely reflects the primary deficits in central postural control network, likely promoting the defective postural motor pattern in camptocormia. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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