ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Tryptophan Metabolite Indole-3-Aldehyde Induces AhR and c-MYC Degradation to Promote Tumor Immunogenicity.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Gut microbiota-derived metabolites as context-dependent modulators of Nrf2 signaling in inflammation-driven carcinogenesis.Gut microbes · 2026Review
- Indole-3-carboxaldehyde fromGut microbes · 2026Article
- Molecular pathways linking the gut microbiome to antitumor immunity.Trends in microbiology · 2026Review
- Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC): An Aggressive Disease Course and Limitations for Personalized Oncology.Oncology and therapy · 2026Article
- Advances in Exercise-Mediated Regulation of the Gut Microbiota via the Muscle-Gut Axis: Implications for Tumor Immunity and Treatment Responses.Metabolites · 2026Review
- Bidirectional Modulation of the Tumor Immune Microenvironment by Gut Microbiota-Derived Indoles: Mechanisms and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Postbiotics as Multifunctional Bioactives: Mechanistic Insights and Translational Applications in Host Physiology and Microbial Ecosystem Modulation.Microorganisms · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Tryptophan-Restricted Intermittent Diet Alleviates Estrogen Deficiency-Induced Osteoporosis via Regulating Coupling Effects of "Gut-Bone" Axis.International journal of biological sciences · 2026Article
- The gut-skin axis in melanoma: from microbial regulatory mechanisms to clinical translation for precision management.Frontiers in microbiology · 2026Review
- Indole-3-Carbaldehyde fromResearch (Washington, D.C.) · 2026Article
- Epithelial AhR Suppresses Allergen-Induced Oxidative Stress and Senescence via c-Myc Regulation.Antioxidants (Basel, Switzerland) · 2025Article
- Review
- Review
- Tryptophan Metabolite Indole-3-Aldehyde Induces AhR and c-MYC Degradation to Promote Tumor Immunogenicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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20 authors.
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Abstract
The role of tryptophan (Trp) and its metabolites in immune regulation is well-established, however, whether and how they regulate immunogenicity of tumor cells is not completely understood. In this study, a range of Trp metabolites are evaluated for their potential to modulate tumor immunogenicity using a co-culture assay with tumor cells and T cells. Indole-3-aldehyde (I3A) is identified as an indole derivative that significantly enhances tumor immunogenicity both in vitro and in vivo. This enhancement is attributed to the upregulation of antigen presentation and immunogenic molecules on tumor cells by I3A, thereby promoting their immunogenicity. Mechanistically, I3A induces the activation and degradation of Aryl hydrocarbon receptor (AhR), leading to increased expression of MHC-I molecules on tumor cell surfaces. Meantime, I3A induces rapid degradation of c-MYC in tumor cells and further enhances T cell activation. In mouse melanoma and lymphoma models, I3A demonstrates immune-dependent antitumor effects and enhances the efficacy of adoptive OT-I T cell therapy. Moreover, overexpression of the Trp metabolic enzyme interleukin-4-induced gene-1 (IL4I1) in tumor cells increases the intracellular level of I3A and enhances tumor immunogenicity. In summary, I3A is identified as a tumor immunogenicity inducer, which holds the potential to enhance antitumor immunotherapy efficacy.
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