ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Nanoimmunomodulation for cartilage repair in osteoarthritis: reprogramming the inflammatory joint microenvironment.International journal of pharmaceutics: X · 2026Review
- A Piezo-Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanism driven adaptation of smart hydrogels to the osteoarthritis pathological microenvironment.Frontiers in bioengineering and biotechnology · 2026Review
- Formulation Progress, Challenges, and Perspectives of Anti-Inflammatory Natural Products.Drug design, development and therapy · 2026Review
- Antler stem cell-derived exosomes restore periodontal homeostasis in a rat model with diabetic periodontitis through enhancing ROS scavenging and osteogenesis.Cell death discovery · 2025Article
- Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Osteoarthritis (OA) is a typical degenerative disease characterized primarily by the degeneration of cartilage. However, current treatments for cartilage degeneration often lead to the formation of hypertrophic cartilage and fibrocartilage, making it challenging to achieve full-thickness cartilage. Here, dual-modular hydrogel microparticles (dmHMPs) are developed, which enable precise spatio-temporal modulation and dynamic equilibrium between immune responses and cartilage regeneration. dmHMPs can modulate the inflammatory microenvironment of the joint by promoting the polarization of synovial macrophages toward an anti-inflammatory phenotype. Consequently, as inflammation is mitigated, synovium-derived mesenchymal stem cells recruited by dmHMPs can efficiently undergo chondrogenic differentiation to repair damaged cartilage in situ. In vivo experiments demonstrate that dmHMPs significantly suppress the expression of Indian hedgehog (Ihh) and collagen type X, thereby reducing the formation of hypertrophic cartilage and preserving the structural integrity and biological functions of articular cartilage. This therapeutic modulates the dynamic balance between inflammation and repair, providing a promising approach for full-thickness cartilage regeneration.
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Registered trials
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