Evidence map›Paper›PMID 40583170›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis.

Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dahe ZhangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, No. 639, Zhi zao ju Road, Shanghai, 200011, China.
Yuxin ZhangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, No. 639, Zhi zao ju Road, Shanghai, 200011, China.
Simo XiaDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, No. 639, Zhi zao ju Road, Shanghai, 200011, China.
Lu ChenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, No. 639, Zhi zao ju Road, Shanghai, 200011, China.
Pei ShenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, No. 639, Zhi zao ju Road, Shanghai, 200011, China.
Chi YangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, No. 639, Zhi zao ju Road, Shanghai, 200011, China.ORCID 0000-0003-1630-5389

Funding

Biological Sample Project of Dominant Diseases, the Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine YBKA201908National Key R&D Program of China 2023YFC2509100National Natural Science Foundation of China 82071134National Natural Science Foundation of China 82370980National Natural Science Foundation of China 82401148Natural Science Foundation of Shanghai 22ZR1437600Science and Technology Commission of Shanghai Municipality 23Y31900400Shanghai's Top Priority Research Center 2022ZZ01017
6 · The paper itself

Abstract

Temporomandibular joint osteoarthritis (TMJOA) is one of the most complex temporomandibular disorders. Cartilage matrix degradation results in the infiltration of nerves, blood vessels, and inflammatory cells, which disrupts chondrocyte function. Therapeutic strategies for TMJOA designed to maintain cartilage homeostasis remain largely unknown. Here, it is reported that orosomucoid 1 (ORM1) attenuated TMJOA progression by maintaining cartilage homeostasis. It is demonstrated that ORM1 is down-regulated in the synovial fluid of patients with TMJOA and condylar cartilage of unilateral anterior crossbite (UAC) rats. Administration of ORM1 protein significantly inhibited cartilage matrix degradation and alleviated TMJOA progression in UAC rats. At the mechanistic level, ORM1 binds to vimentin (VIM), a type III intermediate filament cytoskeletal protein, and inhibits the mitogen-activated protein kinase (MAPK) pathway, thereby significantly decreasing cartilage matrix degradation mediated through inhibiting the cartilage degradation markers matrix metalloproteinase 13 (MMP13) and MMP3, and maintaining cartilage homeostasis. Notably, inhibition of VIM in vivo also markedly improved TMJOA progression, including cartilage degradation and subchondral bone destruction. In conclusion, these findings demonstrate the important functions of ORM1 in maintaining cartilage homeostasis via suppressing VIM/MAPK/MMP signaling and suggest that ORM1 is a promising target for therapeutic intervention in TMJOA.

Indexed as

Cartilage, ArticularOsteoarthritisTemporomandibular Joint DisordersAnimalsChondrocytesDisease Models, AnimalFemaleHomeostasisHumansMaleRatsRats, Sprague-DawleySynovial FluidTemporomandibular Jointcartilageorosomucoidosteoarthritistemporomandibular jointvimentin

Identifiers

PMID40583170
PMCPMC12463022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.