Evidence map›Paper›PMID 40583158›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness-Mediated Bimodal PD-L1/CXCL10 Regulation.

Tian Zhang, Yuan Li, Bo Cheng, Zhao Xu, Mengjie Liu, Jinteng Feng, Yixue Bai, Yang Yu, Panpan Jiang, Luying Geng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tian ZhangDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, P. R. China.ORCID https://orcid.org/0009-0002-2604-5648
Yuan LiThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.ORCID https://orcid.org/0000-0001-8712-2470
Bo ChengThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Zhao XuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Mengjie LiuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Jinteng FengThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Yixue BaiDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Yang YuDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Panpan JiangDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Luying GengDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Feng XuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.ORCID https://orcid.org/0000-0003-4351-0222
Hui GuoDepartment of Medical Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, P. R. China.

Funding

Fundamental Research Funds for Central Universities, Interdisciplinary Team of Tumor Immunotherapy and Physical Microenvironment xtr062021001National Natural Science Foundation of China 12102334National Natural Science Foundation of China 12225208National Natural Science Foundation of China 82072701"SanQin Scholar" Innovation Team of Shaanxi Province 2021-32
6 · The paper itself

Abstract

Immunotherapy efficacy in NSCLC is significantly reduced upon liver metastasis due to profound alterations in the tumor microenvironment, characterized by the absence of cyclic mechanical stretch and increased extracellular matrix (ECM) stiffness. However, the mechanisms underlying the synergistic regulation of these two mechanical cues on the immunotherapy response in NSCLC cells remain poorly understood. In this study, it is demonstrated that both mechanical and biochemical activation of the mechanosensitive ion channel Piezo 1 induces nuclear translocation of YAP, thereby promoting an immunotherapy-responsive tumor immune microenvironment (TIME) through enhanced expression of PD-L1 and secretion of chemokine C-X-C ligand 10 (CXCL10, chemokine recruiting CD8

Indexed as

B7-H1 AntigenCarcinoma, Non-Small-Cell LungChemokine CXCL10ImmunotherapyIon ChannelsLiver NeoplasmsLung NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorExtracellular MatrixHumansMiceTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanChemokine CXCL10CXCL10 protein, humanIon ChannelsPIEZO1 protein, humanmechanomedicineNSCLC liver metastasisorgan‐specific heterogeneitytumor immune microenvironmenttumor physical microenvironment

Identifiers

PMID40583158
PMCPMC12407327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.