Evidence map›Paper›PMID 40583111›Full record

ArticleObesity (Silver Spring, Md.)2025

Lipid-associated macrophages are more abundant in subcutaneous than visceral adipose tissue in patients with obesity.

Marjorie Reyes-Farias, Pablo Fernández-García, Patricia Corrales, Lorena González, David Navarro-Sanagustín, Andrea Soria-Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, José M Balibrea and 8 more

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Adipose-Tissue Macrophage Diversity and Functions.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marjorie Reyes-FariasInstitut de Recerca Germans Trias i Pujol, Barcelona, Spain.
Pablo Fernández-GarcíaDepartment of Basic Health Sciences, Alcorcón Campus, Rey Juan Carlos University, Madrid, Spain.ORCID https://orcid.org/0000-0001-8018-5954
Patricia CorralesDepartment of Basic Health Sciences, Alcorcón Campus, Rey Juan Carlos University, Madrid, Spain.ORCID https://orcid.org/0000-0002-9817-8389
Lorena GonzálezInstitut de Recerca Germans Trias i Pujol, Barcelona, Spain.
David Navarro-SanagustínDepartment of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona, Universitat de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0003-4972-8193
Andrea Soria-GondekPediatric Surgery Department, Hospital Germans Trias i Pujol, Badalona, Spain.
Silvia PelliteroEndocrinology Department, Hospital Germans Trias i Pujol, Badalona, Spain.
Jordi TarascóGeneral Surgery Department, Hospital Germans Trias i Pujol, Badalona, Spain.
Pau MorenoGeneral Surgery Department, Hospital Germans Trias i Pujol, Badalona, Spain.
José M BalibreaCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Laia GatellGeneral Surgery Department, Hospital Germans Trias i Pujol, Badalona, Spain.
Lauro SumoyInstitut de Recerca Germans Trias i Pujol, Barcelona, Spain.
María GalánDepartment of Basic Health Sciences, Alcorcón Campus, Rey Juan Carlos University, Madrid, Spain.
Ester MartínezDepartment of Basic Health Sciences, Alcorcón Campus, Rey Juan Carlos University, Madrid, Spain.
Francesc VillarroyaCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Rubén CereijoCentro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Laura HerreroDepartment of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona, Universitat de Barcelona, Barcelona, Spain.
David Sánchez-InfantesInstitut de Recerca Germans Trias i Pujol, Barcelona, Spain.ORCID https://orcid.org/0000-0001-6086-7501

Funding

Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición CB06/03/0001Generalitat de Catalunya 2021SGR00367Instituto de Salud Carlos III PI17/00145Instituto de Salud Carlos III PI20/00807Ministerio de Ciencia, Innovación y Universidades and the European Regional Development Fund (ERDF) PID2020-114953RB-C21Ministerio de Ciencia, Innovación y Universidades and the European Regional Development Fund (ERDF) PID2023-148783OB-I00
6 · The paper itself

Abstract

objectiveBecause white adipose tissue is infiltrated by several immune cells and their signature in individuals with obesity has not been fully characterized, we wanted to study the most abundant population, which is macrophages, a subtype of myeloid cell.

methodsTo address this objective, we performed transcriptomic analysis of subcutaneous adipose tissue (SAT)- and visceral adipose tissue (VAT)-infiltrated CD11b

resultsOur results showed that gene expression in human white adipose tissue-infiltrated CD11b

conclusionsThis study characterizes for the first time the macrophage biomarker signature in human VAT- and SAT-infiltrated CD11b

Indexed as

Intra-Abdominal FatMacrophagesObesitySubcutaneous FatAdultAntigens, CDBiomarkersCD11b AntigenFemaleGene Expression ProfilingHumansInsulin ResistanceLipid MetabolismMaleMembrane GlycoproteinsMiddle AgedAntigens, CDBiomarkersCD11b AntigenITGAM protein, humanMembrane GlycoproteinsMRC1 protein, humanReceptors, Immunologic

Identifiers

PMID40583111
PMCPMC12304837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.