Evidence map›Paper›PMID 40583089›Full record

Trial reportInternational urology and nephrology2025

Efficacy and safety of calcitriol therapy for reduction of proteinuria in children with chronic kidney disease: an open-label randomized controlled trial.

Jitendra Meena, Ranjeet W Thergaonkar, Aditi Sinha, R Lakshmy, Arvind Bagga, Pankaj Hari

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jitendra MeenaDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Ranjeet W ThergaonkarDepartment of Pediatrics, Command Hospital, Kolkata, India.
Aditi SinhaDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
R LakshmyDepartment of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Arvind BaggaDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Pankaj HariDivision of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. pankajhari@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeReducing proteinuria in children with chronic kidney disease (CKD) has been shown to slow the progression of kidney damage. Hence, we examined the efficacy of a combination of calcitriol and enalapril as compared to enalapril alone in reducing proteinuria in children with CKD.

methodsChildren aged 3 to 18 years with CKD and proteinuria > 250 mg/m

resultsOf 212 screened children with CKD and proteinuria, 72 (56 boys, mean age 11.2 ± 3.4 yr) were randomized. Baseline characteristics were similar in both groups. Proteinuria decreased from the baseline to the end of therapy by median 1.05 (IQR: 0.04 to 1.87) g/day with the combination therapy as compared to median 0.49 (IQR: 0.03 to 1.33) g/day in enalapril group (P = 0.54). The percentage reduction in proteinuria was 60.4% with the combination therapy and 50.1% with enalapril therapy (P = 0.48). Three patients developed hyperphosphatemia in enalapril therapy; hypercalcemia and hyperkalemia were not observed.

conclusionIn children with CKD, the combination of calcitriol and enalapril did not result in significant reduction in proteinuria than enalapril alone. Combination therapy was tolerated well. Further studies with a larger sample size and a longer duration of follow-up studies are needed. Trial registration https://ctri.nic.in CTRI/2011/10/002086. Registered in October 21, 2011.

Indexed as

CalcitriolEnalaprilProteinuriaRenal Insufficiency, ChronicAdolescentAngiotensin-Converting Enzyme InhibitorsChildChild, PreschoolDrug Therapy, CombinationFemaleGlomerular Filtration RateHumansMaleTreatment OutcomeAngiotensin-Converting Enzyme InhibitorsCalcitriolEnalaprilChronic kidney diseaseEnalaprilKidney failureProteinuriaVitamin D

Identifiers

PMID40583089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.