Evidence map›Paper›PMID 40582768›Full record

ArticleJournal of microbiology and biotechnology2025

Association between Serum Uric Acid Levels and Salivary Microbiota in Patients with Obstructive Sleep Apnea.

Yujia Lu, Wanxin Zhang, Min Yu, Xuehui Chen, Chunyan Liu, Xuemei Gao

Abstract read
In one paragraph

Article in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yujia LuDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
Wanxin ZhangDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
Min YuDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.
Xuehui ChenDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
Chunyan LiuDepartment of Orthodontics, Hebei Key Laboratory of Stomatology and Hebei Technology Innovation Center of Oral Health, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, P.R. China.
Xuemei GaoDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microbiota is associated with obstructive sleep apnea (OSA) and hyperuricemia (HUA), but the relationship between oral microbiota and OSA-related HUA remains unclear. Our study investigated salivary microbiota differences between individuals with OSA and those with both OSA and HUA, and explored the link between oral microbiome alterations and uric acid fluctuations in OSA patients. Seventy-two adults were divided into four groups: controls (n = 20, 33.75 ± 9.46 years), OSA (n = 23, 44.08 ± 13.70 years), OSA with comorbid HUA (OSA+HUA, n = 22, 40.18 ± 9.58 years), and OSA with medication-controlled HUA (n = 7, 44.56 ± 15.14 years). Salivary microbiota and proteomic profiles were analyzed using 16S rRNA sequencing and Astral DIA. OSA and OSA+HUA showed reduced alpha-diversity compared to controls. The OSA+HUA group had increased

Indexed as

HyperuricemiaMicrobiotaSalivaSleep Apnea, ObstructiveUric AcidAdultBacteriaFemaleHumansMaleMiddle AgedProteomicsRNA, Ribosomal, 16SRNA, Ribosomal, 16SUric Acid16S rRNAAstral DIAhyperuricemiaoral microbiomeOSA

Identifiers

PMID40582768
PMCPMC12256837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.