ArticleJournal of microbiology and biotechnology2025
Effects of Acute Abdomen III on Sepsis-Induced Intestinal Damage in a Rat Model.
Article in Journal of microbiology and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The disruptions to intestinal integrity contribute to sepsis-related complications. Acute abdomen III is a traditional Chinese medicine formula. The objective of this research is to investigate the impact of acute abdomen III upon sepsis-induced intestinal damage. A rat model of cecal ligation and puncture was used to evaluate the impact of acute abdomen III on sepsis-induced intestinal damage. Histopathological analysis of intestinal tissue damage, detection of systemic inflammation and measurement of tight junction protein were performed by hematoxylin and eosin staining, enzyme-linked immunosorbent assay, and Western blot, respectively. Oxidative stress and intestinal barrier integrity were assessed. Terminal deoxynucleotidyl transferase dUTP nick end labeling was employed to evaluate apoptosis. Expression levels of the apoptosis-related proteins were examined. Model rats treated with acute abdomen III exhibited significantly mitigated intestinal damage. Acute abdomen III treatment reduced systemic inflammation and oxidative stress, as evidenced by downregulation of malondialdehyde and upregulation of superoxide dismutase and catalase. Acute abdomen III therapy lowered endotoxin, D-lactate, and diamine oxidase levels, while boosting the levels of tight junction proteins ZO-1, claudin-1 and occludin, implying an enhancement in intestinal barrier integrity. Acute abdomen III also markedly suppressed apoptosis in intestinal epithelial cells. Acute abdomen III can protect against sepsis-induced intestinal damage by reducing systemic inflammation and oxidative stress while promoting intestinal barrier integrity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.