Evidence map›Paper›PMID 40582730›Full record

ReviewCardiology clinics2025

Nonatherosclerotic Cardiovascular Disease in Chronic Kidney Disease.

Nishigandha Pradhan, Mirela Dobre

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiology clinics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nishigandha PradhanDivision of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; School of Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: Nishigandha.Pradhan@uhhospitals.org.
Mirela DobreDivision of Nephrology and Hypertension, University Hospitals Cleveland Medical Center, Cleveland, OH, USA; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Funding

Myocardial Fibrosis in Hypertensive Adults with and without Chronic Kidney DiseaseR01HL141846 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI DOBRE, MIRELA AURORA · 2018 to 2022
$2.0M
NHLBI NIH HHS R01 HL141846
6 · The paper itself

Abstract

Nonatherosclerotic cardiovascular disease (CVD) in chronic kidney disease (CKD) is highly prevalent and involves distinct pathophysiological mechanisms. Arteriosclerosis, characterized by medial arterial layer thickening and fibrosis, leads to increased arterial stiffness and vascular calcification, driven by disordered bone mineral metabolism. Clinical manifestations of nonatherosclerotic CVD include left ventricular hypertrophy, which occurs in up to 70% to 80% of patients with advanced CKD, heart failure (often with preserved ejection fraction), valvular heart disease, and both fatal and nonfatal arrhythmias. These conditions are exacerbated by CKD-specific factors such as volume overload, anemia, and sympathetic overactivity, contributing to high cardiovascular morbidity and mortality.

Indexed as

Cardiovascular DiseasesRenal Insufficiency, ChronicGlobal HealthHumansRisk FactorsChronic kidney diseaseNonatherosclerotic cardiovascular diseaseUremic cardiomyopathy

Identifiers

PMID40582730
PMCPMC12934252

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.